A recent Cochrane review estimated GeneXpert MTB/RIF specificity for rifampin resistance as 98% (95% confidence interval [CI], 97 to 99), based on results from earlier test versions. The measured positive predictive value of the new generation test from programmatic implementation in Cape Town, South Africa, was 99.5% (95% CI, 98.5 to 100), confirming excellent specificity.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3911341PMC
http://dx.doi.org/10.1128/JCM.02517-13DOI Listing

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