Urosepsis can progress toward severe sepsis, septic shock, and, ultimately, death. Rapid antimicrobial susceptibility testing is crucial to decrease mortality and morbidity. This report shows that isothermal microcalorimetry can provide an antibiogram within 7 h with a sensitivity of 95% and specificity of 91% using Vitek-2 system as a reference.
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http://dx.doi.org/10.1128/JCM.02374-13 | DOI Listing |
Chemphyschem
January 2025
Institute of Energy: Sustainability, Environment, and Equity (I:SEE), Stony Brook University, Stony Brook, New York, 11794, United States of America.
For batteries to function effectively all active material must be accessible requiring both electron and ion transport to each particle. A common approach to generating the needed conductive network is the addition of carbon to create a composite electrode. An alternative approach is the electrochemically induced formation of conductive reaction products where the electrochemically generated materials are in intimate contact with the active material contributing to effective connection of each active particle.
View Article and Find Full Text PDFCarbohydr Polym
March 2025
Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Faculty of Pharmacy, Instituto de Materiales (iMATUS), and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain. Electronic address:
Biofilm formation on biological and material surfaces represents a heavy health and economic burden for both patient and society. To contrast this phenomenon, medical devices combining antibacterial and pro-wound healing abilities are a promising strategy. In the present work, Xanthan gum/Guar gum (XG/GG)-based scaffolds were tuned with thymol and Zn to obtain wound dressings that combine antibacterial and antibiofilm properties and favour the healing process.
View Article and Find Full Text PDFAnaerobe
October 2023
UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London, WC1N 1AX, United Kingdom.
Objectives: In this work, an isothermal microcalorimeter was applied to investigate the antipathogenic activity of three probiotics (Lactobacillus acidophilus, Bifidobacterium lactis and Bifidobacterium bifidum) against Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli using the probiotics in mixed culture with the pathogenic microorganisms.
Methods: A microcalorimeter was used to monitor the growth of the microorganisms as pure cultures and as co-cultures at 37 °C. Relative growths of the probiotics and pathogenic species were determined after microcalorimetric measurements by serial dilution and plate incubation.
J Chem Inf Model
October 2024
Division of Pharmacy and Optometry, The University of Manchester, Manchester M13 9PT, U.K.
Nat Commun
October 2024
Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Spread of multidrug-resistant Pseudomonas aeruginosa strains threatens to render currently available antibiotics obsolete, with limited prospects for the development of new antibiotics. Lytic bacteriophages, the viruses of bacteria, represent a path to combat this threat. In vitro-directed evolution is traditionally applied to expand the bacteriophage host range or increase bacterial suppression in planktonic cultures.
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