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Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody. | LitMetric
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Regulatory T cells are redirected to kill glioblastoma by an EGFRvIII-targeted bispecific antibody.

Bryan D Choi Patrick C Gedeon Luis Sanchez-Perez Darell D Bigner John H Sampson

Oncoimmunology

Duke Brain Tumor Immunotherapy Program; Division of Neurosurgery; Department of Surgery; Duke University Medical Center; Durham, NC USA ; The Preston Robert Tisch Brain Tumor Center at Duke; Duke University Medical Center; Durham, NC USA.

Published: December 2013

Regulatory T cells (Tregs) play a central role in in tumor escape from immunosurveillance. We report that a bispecific T-cell engager (BiTE) targeting a mutated form of the epidermal growth factor receptor, i.e., EGFRvIII, potently redirects Tregs to kill glioblastoma through the granzyme-perforin pathway.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891636PMC
http://dx.doi.org/10.4161/onci.26757DOI Listing

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