Uveitis as a Result of MAP Kinase Pathway Inhibition.

Case Rep Ophthalmol

Royal Surrey County Hospital NHS Foundation Trust, Guildford, Surrey, London, UK ; Faculty of Medicine, Imperial College London, London, UK.

Published: September 2013

We report the case of a patient treated with dabrafenib and trametinib (mitogen-activated protein kinase pathway inhibitors) for stage 3b cutaneous melanoma who developed bilateral uveitis. Although there have been reports of ocular side effects with this class of drugs, uveitis has not been previously reported to the best of our knowledge. This case indicates the wide range of side effects that can be seen with the newer targeted biological therapies.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901607PMC
http://dx.doi.org/10.1159/000357060DOI Listing

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