AI Article Synopsis
- Radiation-induced necrosis is a serious complication resulting from brain irradiation, and there are limited treatment options available.
- Two patients with metastatic melanoma experienced significant improvements in symptoms and imaging results after being treated with low-dose bevacizumab.
- The study suggests that low-dose bevacizumab, administered at doses as low as 5 mg/kg every 6 weeks, may be an effective treatment for managing edema caused by radiation necrosis.
Article Abstract
Background: Radiation-induced necrosis is a complication of brain irradiation. Treatment options are limited.
Methods: The response to treatment with low-dose bevacizumab in 2 patients with radiation-induced necrosis was reported.
Results: Both patients with metastatic melanoma, aged 48 and 51 years, had significant symptomatic and radiological improvement with low-dose bevacizumab treatment. Doses as low as 5 mg/kg every 6 weeks and 7.5 mg/kg i.v. every 4 weeks were used and were highly effective.
Conclusions: Low-dose bevacizumab is a solid option in the management of edema associated with radiation necrosis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3901601 | PMC |
| http://dx.doi.org/10.1159/000357401 | DOI Listing |
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