AI Article Synopsis
- The study investigates the link between a genetic variation in the SEPS1 gene and the risk of developing Hashimoto's thyroiditis (HT), focusing on a specific single-nucleotide polymorphism (rs28665122).
- A case-control study was conducted with 997 participants, including 481 patients with HT and 516 controls, revealing a significant association between certain genetic genotypes and a higher likelihood of HT.
- Results indicate that carriers of the A allele of SEPS1 have an increased risk, especially among male patients, suggesting that selenoproteins may play a role in autoimmune thyroid diseases.
Article Abstract
Context: The association between selenium and inflammation and the relevance of selenoproteins in follicular thyroid cell physiology have pointed to a putative role of selenoproteins in the pathogenesis of autoimmune thyroid diseases.
Objective: The aim of this study was to evaluate the role of a promoter variation in SEPS1, the selenoprotein S gene, in the risk for developing Hashimoto's thyroiditis (HT).
Design: A case-control study was performed to assess the association of genetic variation in the SEPS1 gene (SEPS1 -105G/A single-nucleotide polymorphism, rs28665122) and HT.
Setting: The study was conducted in north Portugal, Porto, in the period of 2007-2013.
Patients Or Other Participants: A total of 997 individuals comprising 481 HT patients and 516 unrelated controls were enrolled in the study.
Main Outcome Measures: Genetic variants were discriminated by real-time PCR using TaqMan single-nucleotide polymorphism genotyping assays.
Results: There is a significant association between the SEPS1 -105 GA and AA genotypes and HT [odds ratio (OR) 2.24, confidence interval (CI) 1.67-3.02, P < 5.0 × 10(-7), and OR 2.08, CI 1.09-3.97, P = .0268, respectively]. The A allele carriers are in higher proportion in the patient group than in the control population (46.2% vs 28.1%, P < 5.0 × 10(-7)) with an OR (CI) of 2.22 (1.67-2.97). The proportion of patients carrying the A allele is significantly higher in male patients with HT, representing a 3.94 times increased risk (P = 7.9 × 10(-3)).
Conclusion: Our findings support the existence of a link between SEPS1 promoter genetic variation and HT risk.
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| http://dx.doi.org/10.1210/jc.2013-3539 | DOI Listing |
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