AI Article Synopsis
- The Rit subfamily of GTPases is part of the Ras family of small G-proteins and features unique sequences in specific regions, influencing its function.
- Rit proteins play a crucial role in various signal transduction pathways, impacting different processes compared to other Ras family members.
- The study focuses on the materials and methods used to examine how Rit proteins influence neuronal differentiation and survival.
Article Abstract
The Rit subfamily of GTPases is a founding branch within the Ras family of small G-proteins and preserves unique sequences in the G2 effector loop domain and the C-terminus. Rit proteins regulate a diversity of signal transduction pathways, some of which are similar to and others of which differ from the pathways that are regulated by other Ras family GTPases. Rit proteins have been demonstrated to be essential regulators in neuronal differentiation and survival. Here, we describe the materials and methods utilized to characterize cellular signaling for the Rit subfamily of G-proteins in neuronal differentiation and survival.
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