AI Article Synopsis
- Staphylococcus aureus and Staphylococcus epidermidis are significant pathogens responsible for hospital infections and can attach to medical devices by forming biofilms.
- PNAG is a polysaccharide found on both bacteria that can trigger antibody production, providing protection against these infections in animal models.
- The study involves synthesizing various PNAG sugar fragments and bonding them to bovine serum albumin using reductive amination for potential vaccine development.
Article Abstract
Staphylococcus aureus and Staphylococcus epidermidis are prominent bacterial pathogens of nosocomial infections. Both microorganisms colonize medical devices by forming adherent biofilms. Poly-β-D-(1→6)-N-acetyl-glucosamine (PNAG) is a surface polysaccharide antigen which was found on both S. aureus and S. epidermidis. Animal studies have proved that PNAG can elicit antibodies which protect against staphylococcal infections. We have presented the synthesis of di-, tetra- and hexasaccharide fragments of PNAG with formyl-heptyl aglycone and their attachment to bovine serum albumin (BSA) by reductive amination.
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| http://dx.doi.org/10.1016/j.carres.2013.12.022 | DOI Listing |
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