Purpose Of Review: The development of new reproductive medicine techniques creates opportunities for preserving fertility in transgender persons. Before, losing fertility was accepted as the price to pay for transitioning.
Recent Findings: The desire for children is present in many trans persons, as in the general population. Ethical concerns are sometimes raised against the preservation of fertility; however, the only unique aspect of this group is the gender transition of one of the parents. All other elements such as same sex parenthood, use of donor gametes, social stigma, etc., can be found in other groups of parents. Not all reproductive options for all trans persons are equal because not only the gametes are of importance, but also the sex of the (future) partner. In trans women, the best option to preserve gametes is cryopreservation of sperm by preference initiated before starting hormonal therapy. In trans men, donor sperm is most often used, but in theory, there are three options available to preserve fertility: oocyte banking, embryo banking and banking of ovarian tissue.
Summary: Fertility is possible for both trans men and women, but it requires timely cryopreservation of gametes or stopping cross-sex hormones and possible fertility treatments which are costly and may be unpleasant. Centers should elucidate their policy and inform trans persons on the possibilities and limitations.
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http://dx.doi.org/10.1097/01.med.0000436184.42554.b7 | DOI Listing |
Bioprocess Biosyst Eng
January 2025
Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Korea.
p-Coumaric acid (p-CA), an invaluable phytochemical, has novel bioactivities, including antiproliferative, anxiolytic, and neuroprotective effects, and is the main precursor of various flavonoids, such as caffeic acid, naringenin, and resveratrol. Herein, we report the engineering of Escherichia coli for de novo production of p-CA via the PAL-C4H pathway. As the base strain, we used the E.
View Article and Find Full Text PDFEpigenetics
December 2025
Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Perceived discrimination, recognized as a chronic psychosocial stressor, has adverse consequences on health. DNA methylation (DNAm) may be a potential mechanism by which stressors get embedded into the human body at the molecular level and subsequently affect health outcomes. However, relatively little is known about the effects of perceived discrimination on DNAm.
View Article and Find Full Text PDFISA Trans
January 2025
School of Electrical Engineering, University of Jinan, Jinan, Shandong 250022, China. Electronic address:
This paper focuses on the issue of global practical tracking control by output feedback for uncertain nonlinear systems with unknown control coefficients and unknown reference signal. Unlike other tracking works, the upper and lower bounds of the unknown control coefficients in the studied nonlinear system are not required to be known, while the nonlinearities are bounded by the unmeasured states multiplying an unknown constant, the polynomial-of-output and the polynomial-of-input. Inspired by related works, an adaptive tracking controller based on a new dynamic high gain has been successfully constructed by combining the universal control idea and the concept of dead-zone with backstepping technique, which effectively handles the impacts of multiple uncertainties.
View Article and Find Full Text PDFISA Trans
January 2025
University of Science and Technology of China, Hefei 230027, China. Electronic address:
This paper investigates the self-triggered control for stabilizing an n-dimensional linear time-invariant system under communication constraints, including finite bit rates and transmission delay. The concerned system is further perturbed by bounded process noise. To resolve these issues, a self-triggering strategy is proposed.
View Article and Find Full Text PDFISA Trans
January 2025
State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai 200240, China. Electronic address:
This paper addresses the critical challenge of interpretability in machine learning methods for machine fault diagnosis by introducing a novel ad hoc interpretable neural network structure called Sparse Temporal Logic Network (STLN). STLN conceptualizes network neurons as logical propositions and constructs formal connections between them using specified logical operators, which can be articulated and understood as a formal language called Weighted Signal Temporal Logic. The network includes a basic word network using wavelet kernels to extract intelligible features, a transformer encoder with sparse and structured neural attention to locate informative signal segments relevant to decision-making, and a logic network to synthesize a coherent language for fault explanation.
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