AI Article Synopsis
- This work introduces the first use of Laser Speckle Contrast Imaging (LSCI) with extended depth of field (DOF) for better imaging of blood flow.
- It utilizes wavefront coding to enhance flow speed measurement, achieving a two-fold increase in DOF compared to conventional methods.
- The system is tested in controlled experiments and successfully applied to the in-vivo imaging of a rat's somatosensory cortex, enabling clearer visualization of multiple blood vessels at once.
Article Abstract
This work presents, to our knowledge, the first demonstration of the Laser Speckle Contrast Imaging (LSCI) technique with extended depth of field (DOF). We employ wavefront coding on the detected beam to gain quantitative information on flow speeds through a DOF extended two-fold compared to the traditional system. We characterize the system in-vitro using controlled microfluidic experiments, and apply it in-vivo to imaging the somatosensory cortex of a rat, showing improved ability to image flow in a larger number of vessels simultaneously.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891325 | PMC |
| http://dx.doi.org/10.1364/BOE.5.000123 | DOI Listing |
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