The rare zymodeme, Leishmania tropica MON-58, was isolated from a young Afghan refugee with a facial cutaneous lesion who had come to live in Crete early 2008. The same zymodeme variant was isolated from a local dog that had never travelled outside the island, with symptoms of visceral leishmaniasis, which stayed in the area where the patient worked during the summer months. This is the first record of L. tropica in a host, other than human, in Greece and another example of introduction of a vector borne pathogen in a focus where local vector/s can sustain it, with the risk of initiation of new transmission cycle/s.
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http://dx.doi.org/10.1016/j.actatropica.2014.01.003 | DOI Listing |
Parasitol Int
December 2024
Manisa Celal Bayar University, Medical Faculty, Department of Parasitology, Manisa, Turkey.
This study aims to identify the most sensitive colorimetric test for assessing intracellular drug susceptibility of Leishmania tropica to conventional antileishmanial drugs. To this end, the efficacy of four colorimetric methods-MTT, XTT, MTS, and WST-8-was compared using reference L. tropica promastigotes.
View Article and Find Full Text PDFPLoS Negl Trop Dis
December 2024
Laboratory of Molecular Epidemiology and Experimental Pathology, Institut Pasteur de Tunis, Université de Tunis El Manar, Tunis, Tunisia.
Background: Cutaneous Leishmaniases (CL), highly endemic in Africa and Mediterranean region, are caused by different Leishmania parasite species. Accurate species identification is crucial for effective diagnosis, treatment, and control of these diseases, but traditionally relies on DNA-based methods. High Resolution Melting analysis PCR (HRM PCR) provides rapid results and precise differentiation based on nucleotide variations.
View Article and Find Full Text PDFActa Trop
December 2024
Department of Parasitology, Faculty of Medicine, Ege University, Izmir, Turkey; Department of Basic Oncology, Institute of Health Sciences, Ege University, Izmir, Turkey; Translational Pulmonary Research Center (EGESAM), Ege University, Izmir, Turkey. Electronic address:
Leishmaniasis is a neglected infectious disease that affects millions of people worldwide. Visceral leishmaniasis (VL) caused by Leishmania infantum and cutaneous leishmaniasis (CL) caused by L. major/ L.
View Article and Find Full Text PDFParasit Vectors
December 2024
INSERM UMR-S-MD 1197, Ministère des Armées et Université Paris Saclay, Villejuif, France.
Background: Leishmania is the causal parasite of leishmaniasis, a neglected tropical disease affecting millions of individuals worldwide, and its dissemination is linked to climate change. Despite the complexity and effectiveness of the immune response, the parasite has developed many strategies to evade it and take control of the host cell to replicate. These evasion strategies start at early stages of infection by hijacking immune receptors to mitigate the cellular response.
View Article and Find Full Text PDFFront Epidemiol
December 2024
Laboratory of Biology and Health, Ibn Tofail University, Kénitra, Morocco.
Introduction: Leishmaniasis is a highly prevalent neglected tropical disease. It represents a significant public health concern in northern Africa, particularly in Morocco. To assess the extent of the disease at the provincial level, as well as the temporal evolution of CL cases and their geographic distribution.
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