AI Article Synopsis
- Animal models help researchers understand how the brain deteriorates and recovers after a stroke.
- The review focuses on modern techniques like electroencephalography and magnetic resonance imaging in studying stroke in rodents.
- Improving these methods could enhance diagnostic capabilities and lead to the discovery of new treatments for stroke.
Article Abstract
Animal models are useful tools for better understanding the mechanisms underlying neurological deterioration after an ischemic insult as well as subsequent evolution of changes and recovery of functions. In response to the updated requirements for preclinical investigations of stroke to include relevant functional measurement techniques and biomarker endpoints, we here review the state of knowledge on application of some translational electrophysiological and neuroimaging methods, and in particular, electroencephalography monitoring and magnetic resonance imaging in rodent models of ischemic stroke. This may lead to improvement of diagnostic methods and identification of new therapeutic targets, which would considerably advance the translational value of preclinical stroke research.
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| http://dx.doi.org/10.1016/j.brainresbull.2014.01.003 | DOI Listing |
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