Among 641 pneumococcal isolates recovered from 2002 to 2012 in Japan, 19 (3.0%) were serotype 35B. Twelve of the 19 were ST558 (single-locus variant of Utah35B-24-ST377) and seven were ST2755. Continuous monitoring of serotypes and their clonal association is important, especially in Japan where PCV7 was licensed only in 2010.
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http://dx.doi.org/10.1016/j.jiac.2013.11.008 | DOI Listing |
Vaccine
January 2025
Department of Pediatrics, Section of Infectious Diseases and Global Health, Yale University School of Medicine, New Haven, CT, United States; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, United States; Yale Institute for Global Health, Yale University, New Haven, CT, United States; Yale Center for Infection and Immunity, Yale University, New Haven, CT, United States. Electronic address:
Background: Pneumococcal conjugate vaccines (PCV) reduced invasive disease, but the overall prevalence of pneumococcal nasopharyngeal colonization among children has not changed significantly. Our knowledge of which serotypes, once colonized, hold a higher likelihood to cause invasive disease is limited.
Methods: Serotype-specific invasive capacity (IC) of Streptococcus pneumoniae was estimated using an enhanced population-based invasive pneumococcal disease (IPD) surveillance in children <7 years of age in Massachusetts and surveillance of nasopharyngeal (NP) colonization in selected Massachusetts communities in corresponding respiratory seasons.
Front Microbiol
November 2024
Faculdades Pequeno Príncipe, Curitiba, Paraná, Brazil.
Invasive pneumococcal disease (IPD) is a major cause of morbidity and mortality worldwide, particularly in the pediatric population (children and infants), with high rates of hospitalization and death. This study aimed to create and validate a classifier for serotyping using Fourier-transform infrared (FT-IR) spectroscopy as a rapid alternative to the classical serotyping technique. In this study, a database comprising 76 clinical isolates, including 18 serotypes (predominantly serotypes 19A, 6C, and 3) of from pediatric patients with IPD, was tested at a tertiary pediatric hospital in southern Brazil during 2016-2023.
View Article and Find Full Text PDFIntern Med
November 2024
Department of Pediatric, Ohta-Nishinouchi Hospital, Japan.
We herein report a case of bacterial meningitis and bacteremia in a 3-month-old boy caused by Streptococcus pneumoniae serotype 35B multidrug resistance. Intravenous ampicillin was administered on admission. However, when pneumococcal meningitis was suspected, the antibiotic treatment was changed to ceftriaxone (CTRX) and vancomycin (VCM).
View Article and Find Full Text PDFNew Microbes New Infect
December 2024
Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
Background: The prevalence of serotypes and antimicrobial resistance of was characterized among children thirteen years after the licensure of the pneumococcal conjugate vaccine (PCV) in Japan.
Methods: A total of 353 pneumococcal isolates were collected from Japanese children between March and July 2023. All the isolates were serotyped using genetic methods and tested for susceptibility to 14 antimicrobial agents.
J Infect Chemother
October 2023
Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan.
Background: Non-vaccine serotype (NVT) pneumococcal pneumonia in Japan has increased with the spread of pneumococcal vaccinations. However, there is no data regarding the clinical background and antimicrobial susceptibility of NVT isolates compared with those of vaccine serotype (VT) isolates in adult pneumococcal pneumonia.
Methods: The serotypes and antimicrobial susceptibilities of pneumococcal isolates obtained from patients with pneumonia at the University of Occupational and Environmental Health, Japan, from January 2011 to December 2020 were retrospectively evaluated along with the patients' clinical information.
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