AI Article Synopsis
- Coronary artery disease causes blockages in arteries, leading to the development of drug eluting stents to prevent re-blockage after treatment.
- Understanding how physical factors affect drug delivery from these stents into the arterial wall is crucial for their effectiveness.
- This study uses numerical models to show that simplified 2D and 1D representations can effectively simulate the more complex 3D structure of arteries and stents, emphasizing that strut compression significantly influences drug delivery.
Article Abstract
Coronary artery disease results in blockages or narrowing of the artery lumen. Drug eluting stents were developed to replace bare metal stents in an effort to combat re-blocking of the lumen. A key element in determining the therapeutic success of a drug eluting stent is an in-depth understanding of the physical factors that affect mass transport of the drug into the arterial wall, over early time periods. The numerical models developed within this study focus on assessing the influence of a host of physical factors that either facilitate or impede therapeutic drug delivery into the arterial wall from the unit cell of an idealised stent. This study demonstrates that model reduction strategies to 2D and 1D can still adequately represent a 3D curved arterial wall and strut polymer coating, respectively, using an idealistic stent geometry. It was shown that the level of strut compression can have a significant impact on therapeutic drug delivery in the arterial wall.
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| http://dx.doi.org/10.1016/j.medengphy.2013.11.013 | DOI Listing |
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