AI Article Synopsis

  • The study investigates the antiulcer properties of a hydroalcoholic extract from Plumeria alba leaves.
  • Various extracts were administered to test their effects on ulcer models induced by NSAIDs, ethanol, and pylorus ligation.
  • Results indicated that specific fractions like EAPA and BPA showed significant ulcer-healing effects, while HAPA and HPA did not, confirming the plant's traditional medicinal use.

Article Abstract

Objective: This study was conducted to evaluate the antiulcerogenic property of hydroalcoholic extract obtained from the leaves of Plumeria alba Linn.

Methods: Antiulcer assays were performed using the protocols of ulcer induced by non-steroidal anti-inflammatory drugs, ethanol and pylorus ligation. The hydroalcoholic extract (HAPA), and various fractions of HAPA like, n-hexane extract (HPA), ethyl acetate extract (EAPA) and n-butanol extract (BPA) were administered at doses of 200 and 400 mg/kg for HAPA and 100 and 200 mg/kg for fractions of extracts. Parameters of gastric secretion (volume, pH, total protein, and free and total acidity) were determined by the pylorus ligation model. Parameters like aspartate aminotransferase and alanine aminotransferase were also determined in ethanol-induced ulcer model. To determine the mechanism of action, role of nitric oxide was also evaluated.

Results: EAPA and BPA (100 and 200 mg/kg, p.o.) showed gastric ulcer-healing effect in indomethacin-induced ulcer model, while HAPA (200 mg/kg) and HPA showed no significant antiulcer effect. Both EAPA and BPA showed gastric cytoprotective effect in ethanol-induced gastric ulcer and inhibited gastric secretion in pylorus-ligated rats.

Conclusion: The results of the present study show that some hydroalcoholic extract of Plumeria alba L. displays antiulcer activity, as demonstrated by the significant inhibition of ulcer formation induced by different models, which is consistent with the literature report in folk medicine.

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Source
http://dx.doi.org/10.1016/S2095-4964(14)60002-9DOI Listing

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