Silica-ZnCl2 has been found to be an efficient and eco-friendly catalyst for the synthesis of substituted 4-methylcoumarins from ethyl acetoacetate and substituted phenols under "neat" conditions in an oil bath at 80°C. The experimental procedure is simple, includes shorter reaction times (15-65 min), compatible with sensitive functional groups, and results in excellent yield of the products.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876838 | PMC |
| http://dx.doi.org/10.1155/2013/132794 | DOI Listing |
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