2-(4-Chloro-phen-yl)-4-phenyl-1,2-di-hydro-quinazoline.

Acta Crystallogr Sect E Struct Rep Online

Laboratoire de Synthèse des Molécules d'Intérêts Biologiques, Département de Chimie, Faculté des Sciences Exactes, Université de Constantine 1, 25000 Constantine, Algeria.

Published: October 2013

In the title compound, C20H15ClN2, the pyrimidine ring is in a flattened half-chair conformation. The phenyl and chloro-substituted benzene rings form dihedral angles of 84.97 (5) and 80.23 (4)°, respectively, with the benzene ring of the di-hydro-quinazoline group. The dihedral angle between the phenyl and chloro-substituted benzene rings is 61.71 (5)°. In the crystal, mol-ecules are arranged in inter-secting layers parallel to (101) and (-102), with N-H⋯N hydrogen bonds linking mol-ecules along [010]. In addition, a weak C-H⋯π inter-action is observed.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884317PMC
http://dx.doi.org/10.1107/S1600536813027839DOI Listing

Publication Analysis

Top Keywords

phenyl chloro-substituted
8
chloro-substituted benzene
8
benzene rings
8
2-4-chloro-phen-yl-4-phenyl-12-di-hydro-quinazoline title
4
title compound
4
compound c20h15cln2
4
c20h15cln2 pyrimidine
4
pyrimidine ring
4
ring flattened
4
flattened half-chair
4

Similar Publications

Noncovalent Synergy: Aurophilicity and Aryl Stacking in Bis(gold(I)aryl)-dmpm Complexes.

Inorg Chem

July 2022

Lehrstuhl für Anorganische Chemie und Strukturchemie; Centrum für Molekulare Materialien CM2, Fakultät für Chemie, Universität Bielefeld, Universitätsstraße 25, Bielefeld D-33615, Germany.

Bis(dimethylphosphino)methane (dmpm) was used as a ligand to synthesize four semi-supported dinuclear gold(I) complexes, dmpm(AuR) (R = Cl, CH, CCl, and CF), which were studied concerning the synergistic effects of two weak noncovalent interactions: aurophilic and aryl-aryl stacking interactions. The chloro-substituted complex was synthesized by the ligand substitution of (tht)AuCl with dmpm and further functionalized by the reaction with PhMgBr or generated CClLi to afford the phenyl- and pentachlorophenyl-substituted compounds, respectively. The pentafluorophenyl-substituted gold complex was generated by the ligand substitution of (tht)Au(CF) with dmpm.

View Article and Find Full Text PDF

Background: Microbial infections together with rising drug resistance pose a threat to immunocompromised individual. In this perspective, compounds with spirooxindolopyrrolidine play a significant role in research on antimicrobial drug delivery research owing to their various pharmaceutical activities. Spiroheterocyclic compounds are present in number of medications as active motif due to their exceptional structural properties which enable for easy interaction with the protein of the biological target.

View Article and Find Full Text PDF

A series of halo-substituted mixed ester/amide-based analogues have been prepared as jack bean urease inhibitor, which showed good to excellent inhibition of enzyme activity. The role of halo-substituted benzoyl moieties and alkyl substituted anilines in urease inhibitory kinetics was also investigated. The alkyl-substituted anilines reacted with chloroacetyl chloride to afford intermediates , which were then reacted with different halo-substituted benzoic acids to prepare the title compounds .

View Article and Find Full Text PDF

As the orexin signaling system is crucial for the regulation of the sleep/wake cycle, inhibitors of orexin-1 and orexin-2 receptors are of significant interest in the treatment of insomnia. Herein, a series of novel azacycloheptane sulfonamide derivatives were designed and synthesized, and all the compounds were evaluated as potential orexin receptor inhibitors by FLIPR Tetra calcium assay. A majority of the tested azacycloheptane sulfonamide derivatives showed OX1R and OX2R inhibitory activity.

View Article and Find Full Text PDF

The separation of 14 chiral sulfoxides was systematically studied on 12 cellulose-based chiral columns in acetonitrile and acetonitrile-water mobile phases. Out of all monosubstituted methylphenylcarbamates of cellulose the one having a methyl moiety in position 3 showed more universal chiral resolving ability compared to 2- and 4-substituted derivatives. Out of disubstituted phenylcarbamates of cellulose the ones with methyl substituents showed higher enantiomer resolving ability compared to chloro-substituted ones and substitution in positions 3 of the phenyl moiety was clearly advantageous.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!