In the title compound, C20H15ClN2, the pyrimidine ring is in a flattened half-chair conformation. The phenyl and chloro-substituted benzene rings form dihedral angles of 84.97 (5) and 80.23 (4)°, respectively, with the benzene ring of the di-hydro-quinazoline group. The dihedral angle between the phenyl and chloro-substituted benzene rings is 61.71 (5)°. In the crystal, mol-ecules are arranged in inter-secting layers parallel to (101) and (-102), with N-H⋯N hydrogen bonds linking mol-ecules along [010]. In addition, a weak C-H⋯π inter-action is observed.
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http://dx.doi.org/10.1107/S1600536813027839 | DOI Listing |
Inorg Chem
July 2022
Lehrstuhl für Anorganische Chemie und Strukturchemie; Centrum für Molekulare Materialien CM2, Fakultät für Chemie, Universität Bielefeld, Universitätsstraße 25, Bielefeld D-33615, Germany.
Bis(dimethylphosphino)methane (dmpm) was used as a ligand to synthesize four semi-supported dinuclear gold(I) complexes, dmpm(AuR) (R = Cl, CH, CCl, and CF), which were studied concerning the synergistic effects of two weak noncovalent interactions: aurophilic and aryl-aryl stacking interactions. The chloro-substituted complex was synthesized by the ligand substitution of (tht)AuCl with dmpm and further functionalized by the reaction with PhMgBr or generated CClLi to afford the phenyl- and pentachlorophenyl-substituted compounds, respectively. The pentafluorophenyl-substituted gold complex was generated by the ligand substitution of (tht)Au(CF) with dmpm.
View Article and Find Full Text PDFJ Infect Public Health
December 2021
Department of Chemistry, College of Science, King Saud University, P.O Box 2455, Riyadh 11451, Saudi Arabia.
Background: Microbial infections together with rising drug resistance pose a threat to immunocompromised individual. In this perspective, compounds with spirooxindolopyrrolidine play a significant role in research on antimicrobial drug delivery research owing to their various pharmaceutical activities. Spiroheterocyclic compounds are present in number of medications as active motif due to their exceptional structural properties which enable for easy interaction with the protein of the biological target.
View Article and Find Full Text PDFBiomed Res Int
May 2021
Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus, Pakistan.
A series of halo-substituted mixed ester/amide-based analogues have been prepared as jack bean urease inhibitor, which showed good to excellent inhibition of enzyme activity. The role of halo-substituted benzoyl moieties and alkyl substituted anilines in urease inhibitory kinetics was also investigated. The alkyl-substituted anilines reacted with chloroacetyl chloride to afford intermediates , which were then reacted with different halo-substituted benzoic acids to prepare the title compounds .
View Article and Find Full Text PDFRSC Adv
August 2020
School of Pharmaceutical Science, Chongqing Medical University Chongqing 400016 China
As the orexin signaling system is crucial for the regulation of the sleep/wake cycle, inhibitors of orexin-1 and orexin-2 receptors are of significant interest in the treatment of insomnia. Herein, a series of novel azacycloheptane sulfonamide derivatives were designed and synthesized, and all the compounds were evaluated as potential orexin receptor inhibitors by FLIPR Tetra calcium assay. A majority of the tested azacycloheptane sulfonamide derivatives showed OX1R and OX2R inhibitory activity.
View Article and Find Full Text PDFJ Chromatogr A
January 2020
Institute of Physical and Analytical Chemistry, School of Exact and Natural Sciences, Tbilisi State University, Chavchavadze Ave. 3, 0179, Tbilisi, Georgia. Electronic address:
The separation of 14 chiral sulfoxides was systematically studied on 12 cellulose-based chiral columns in acetonitrile and acetonitrile-water mobile phases. Out of all monosubstituted methylphenylcarbamates of cellulose the one having a methyl moiety in position 3 showed more universal chiral resolving ability compared to 2- and 4-substituted derivatives. Out of disubstituted phenylcarbamates of cellulose the ones with methyl substituents showed higher enantiomer resolving ability compared to chloro-substituted ones and substitution in positions 3 of the phenyl moiety was clearly advantageous.
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