Melioidosis is an infectious disease caused by the gram-negative bacillus Burkholderia pseudomallei. Melioidosis is endemic in Southeast Asia and northern Australia. An important risk factor for the development of melioidosis is the presence of diabetes mellitus, which may increase the relative risk of infection by as much as 100-fold. We report a rare case of melioidosis of the parotid and submandibular gland with coexisting diabetes. This was successfully managed conservatively with intravenous ceftazidime followed by trimethoprim/sulfamethoxazole and doxycycline.
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West Afr J Med
September 2024
Mental Health Unit, Federal Medical Centre, Jabi, Abuja.
Background: Depression and anxiety disorders frequently co-occur with Type 2 Diabetes Mellitus, leading to poor glycaemic control and quality of life through complex biopsychosocial mechanisms. A dual diagnosis of chronic medical and mental health conditions reduces the probability of early recognition and intervention for either. This study was aimed at assessing the prevalence and correlates of depression and anxiety disorders among persons with Type 2 Diabetes Mellitus in a tertiary hospital in North-West Nigeria.
View Article and Find Full Text PDFJ Clin Med
January 2025
Department of Plastic and Reconstructive Surgery, MedStar Georgetown University Hospital, 3800 Reservoir Road, NW, Washington, DC 20007, USA.
: Medial arterial calcification (MAC), a distinct form of vascular pathology frequently coexisting with peripheral arterial disease (PAD), poses unique challenges in limb salvage among patients with diabetes, chronic kidney disease, and end-stage renal disease. This study examines the incidence of MAC and its impact on limb salvage outcomes over a decade of experience at a tertiary limb salvage center. : A retrospective review of all complex lower extremity (LE) reconstructions using local flap (LF) or free tissue transfer (FTT), performed from July 2011 to September 2022, was conducted.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
Department of Nephrology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
Autophagy and mitophagy are critical cellular processes that maintain homeostasis by removing damaged organelles and promoting cellular survival under stress conditions. In the context of diabetic kidney disease, these mechanisms play essential roles in mitigating cellular damage. This review provides an in-depth analysis of the recent literature on the relationship between autophagy, mitophagy, and diabetic kidney disease, highlighting the current state of knowledge, existing research gaps, and potential areas for future investigations.
View Article and Find Full Text PDFArch Med Res
January 2025
Center for Health Systems Research, Instituto Nacional de Salud Pública, Cuernavaca, Morelos, Mexico. Electronic address:
Background: Longitudinal analysis of multimorbidity (MM) from a holistic approach to the aging population is necessary to guide medical care.
Aims: To estimate the probability of transition between different MM patterns and the "death" stage and to characterize the socioeconomic, health, behavioral, and functional dimensions of MM patterns from a syndemic perspective.
Methods: A cohort of 7,120 people ≥50 from the Mexican Health and Aging Study and mortality data at 11 and 17 years of follow-up were analyzed using the latent class approach.
J ECT
January 2025
From the Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA.
Background: Electroconvulsive therapy (ECT) is an effective treatment for treatment-resistant depression (TRD). There are limited data on the improvement of anxiety symptoms in patients receiving ECT for TRD.
Objective: The aim of the study was to examine the extent to which anxiety symptom severity improves, relative to improvements in depressive symptoms, in TRD patients receiving an acute course of ECT.
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