In this research, electrospray ionization mass spectrometry (ESI-MS) was used to probe the binding selectivity of a flexible cyclic polyamide (cβ) to G-quadruplexes from the long G-rich sequences in the c-myb oncogene promoter. The results show that three G-rich sequences, including d[(GGA)3GGTCAC(GGA)4], d[(GGA)4GAA(GGA)4], and d[(GGA)3GGTCAC(GGA)4GAA(GGA)4] species in the c-myb promoter can form parallel G-quadruplexes, and cβ selectively binds towards these G-quadruplexes over both several other G-quadruplexes and the duplex DNA. These properties of cβ have profound implications on future studies of the regulation of c-myb oncogene expression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s13361-013-0802-y | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Analyses of the Gene in Triple Negative Breast Cancer: Evidence of Regulation of the Gene and Identification of a Specific Exon Overexpressed in Tumor Cell Lines.
Int J Mol Sci
December 2024
Department of Biology, Texas Southern University, Houston, TX 77004, USA.
Previous data show that the knockdown of the gene in the MDA-MB-231 cell line leads to the downregulation of gene expression. In addition, and genes are co-expressed and dysregulated in some of the same triple negative breast cancer patient samples. We propose that the co-expression of the two genes is attributed to the MYBL1 transcription factor regulation of the gene.
View Article and Find Full Text PDFAnalysis of the MYB gene family in tartary buckwheat and functional investigation of FtPinG0005108900.01 in response to drought.
BMC Plant Biol
January 2025
State Key Laboratory of Crop Stress Adaption and Improvement, School of Life Sciences, Henan University, Kaifeng, Henan, 475004, China.
Tartary buckwheat (Fagopyrum tataricum) is an important crop used for edible food and medicinal usage. Drought annually brings reduction in crop yield and quality, causing enormous economic losses. Transcription factors are often involved in the regulation of plant responses to environmental stresses.
View Article and Find Full Text PDFBone-Marrow-Targeted Nanocomposite Abrogates C-Myb-Survivin Cross Talk in MLL-AF9-Rearranged Acute Myeloid Leukemia in and Patient-Derived Xenograft Models.
ACS Appl Mater Interfaces
January 2025
Epigenetics Research Laboratory, Institute of Nano Science and Technology, Knowledge City, Sector 81, Mohali, Punjab 140306, India.
The heterogeneous form of malignancy in the myeloid lineage of normal hematopoietic stem cells (HSCs) is characterized as acute myeloid leukemia (AML). The t(9;11) reciprocal translocation (p22;q23) generates MLL-AF9 oncogene, which results in myeloid-based monoblastic AML with frequent relapse and poor survival. MLL-AF9 binds with the C-Myb promoter and regulates AML onset, maintenance, and survival.
View Article and Find Full Text PDFCharacteristics and Expression Analysis of the MYB-Related Subfamily Gene in .
Int J Mol Sci
November 2024
College of Horticulture, Gansu Agricultural University, Lanzhou 730070, China.
Article Synopsis
- * A total of 100 MYB-related proteins were identified, primarily localized in the nucleus, and mapped across seven chromosomes, with evidence of collinear gene relationships indicating potential evolutionary duplication events.
- * The study found that Motif 3 is the most conserved across MYB-related genes, and specific treatments with ABA and MeJA can influence gene expression, particularly in petals, indicating a significant role for these factors in flower senescence and growth regulation.
Synergistic Strategies for KMT2A-Rearranged Leukemias: Beyond Menin Inhibitor.
Cancers (Basel)
November 2024
Cancer Section, Development Biology and Cancer Programme, UCL GOS Institute of Child Health, London WC1N 1EH, UK.
KMT2A-rearranged leukemias are a highly aggressive subset of acute leukemia, characterized by poor prognosis and frequent relapses despite intensive treatment. Menin inhibitors, which target the critical KMT2A-menin interaction driving leukemogenesis, have shown promise in early clinical trials. However, resistance to these inhibitors, often driven by menin mutations or alternative oncogenic pathways, remains a significant challenge.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!