The capacity of the peripheral blood mononuclears to produce leukocyte (alpha) and immune (gamma) interferons as well as interferon concentrations in the serum were studied in 101 children suffering from lymphosarcoma. In the blood serum of the patients interferon titres did not exceed 4 units/ml. The lowered capacity of the peripheral blood mononuclears to produce one of the interferon species in titres below 32 units/ml is a bad prognostic factor. The syndrome of interferon deficiency in children suffering from lymphosarcoma is observed in one per 5 cases.
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