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Fixed-dose combination fluticasone/formoterol for asthma treatment in a real-world setting: meta-analysis of exacerbation rates and asthma control.
Eur Clin Respir J
February 2023
National Heart and Lung Institute (NHLI), Imperial College London, London, UK.
Background: Treatment guidelines for asthma management are derived almost exclusively from the results of controlled clinical trials undertaken in carefully selected patient populations; meaning that their outcomes may not reflect the true performance of treatments when used in general daily medical practice. The aim of this meta-analysis was to combine the results of observational studies investigating the fluticasone propionate/formoterol (FP/FORM) fixed-dose combination in real-world asthma patients.
Methods: A systemic literature review was completed in March 2019 using the PubMed database.
Pharmacokinetic and Pharmacodynamic Comparison of Fluticasone Propionate/Formoterol Fumarate Administered via a Pressurized Metered-Dose Inhaler and a Novel Breath-Actuated Inhaler in Healthy Volunteers.
J Aerosol Med Pulm Drug Deliv
April 2023
Mundipharma Research Limited, Cambridge, United Kingdom.
Article Synopsis
- The study compared the pharmacokinetics (PK) and systemic effects of fluticasone/formoterol delivered via a breath-actuated inhaler (BAI) versus a pressurized metered-dose inhaler (pMDI) in healthy volunteers.
- Study 1 focused on assessing drug exposure by administering single doses of fluticasone/formoterol through different devices, aiming to confirm that the BAI delivers a similar or better concentration of the drug compared to the pMDI.
- Study 2 involved evaluating the systemic pharmacodynamic (PD) effects of formoterol, specifically monitoring serum potassium levels after administration, confirming the safety and effectiveness of BAI in comparison to pMDI methods.
Inhaled Corticosteroids Selectively Alter the Microbiome and Host Transcriptome in the Small Airways of Patients with Chronic Obstructive Pulmonary Disease.
Biomedicines
May 2022
Centre for Heart Lung Innovation, The University of British Columbia, St. Paul's Hospital, Vancouver, BC V6Z 1Y6, Canada.
Background: Patients with chronic obstructive pulmonary disease (COPD) are commonly treated with inhaled corticosteroid/long-acting ß2-agonist combination therapy. While previous studies have investigated the host-microbiome interactions in COPD, the effects of specific steroid formulations on this complex cross-talk remain obscure.
Methods: We collected and evaluated data from the Study to Investigate the Differential Effects of Inhaled Symbicort and Advair on Lung Microbiota (DISARM), a randomized controlled trial.
Two cases of chronic obstructive pulmonary disease evaluated by dynamic-ventilatory digital radiography for pulmonary function and assessment of treatment efficacy.
Respir Investig
November 2021
Kanazawa University Hospital, Respiratory Medicine, Ishikawa, Japan.
Spirometry is a crucial test used in the diagnosis and monitoring of patients with chronic obstructive pulmonary disease (COPD). Severe acute respiratory syndrome coronavirus 2 pandemic has posed numerous challenges in performing spirometry. Dynamic-ventilatory digital radiography (DR) provides sequential chest radiography images during respiration with lower doses of radiation than conventional X-ray fluoroscopy and computed tomography.
View Article and Find Full Text PDFEffect of combination inhaled therapy on ventilation distribution measured by SPECT/CT imaging in uncontrolled asthma.
J Appl Physiol (1985)
August 2021
Airway Physiology and Imaging Group, The Woolcock Institute of Medical Research, The University of Sydney, Sydney, New South Wales, Australia.
Asthma is characterized by heterogeneous ventilation as measured by three-dimensional ventilation imaging. Combination inhaled corticosteroid/long-acting β-agonist (ICS/LABA) treatment response is variable in asthma, and effects on regional ventilation are unknown. Our aims were to determine whether regional ventilation defects decrease after ICS/LABA treatment and whether small airways dysfunction predicts response in uncontrolled asthma.
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