AI Article Synopsis
- A new, efficient method has been created for synthesizing 4,6-diarylpyrimidin-2(1H)-ones using a one-pot reaction involving atomized sodium in THF.
- This process combines an aldehyde, a methyl ketone, and urea through a Biginelli-like cyclocondensation.
- The reaction requires mild conditions, is cost-effective, and achieves high yields in just 10-15 minutes under ultrasonic agitation.
Article Abstract
A simple and an efficient procedure for the synthesis of 4,6-diarylpyrimidin-2(1H)-ones using atomized sodium/THF via a one-pot three-component Biginelli-like cyclocondensation of an aldehyde, a methyl ketone and urea under ultrasonic condition is developed. The method is mild and inexpensive; yields are high and the reactions go to completion within 10-15 min.
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| http://dx.doi.org/10.1016/j.ultsonch.2013.12.021 | DOI Listing |
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