Chemical investigation of a Formosan sponge Axinyssa sp. has led to the isolation of five nitrogenous bisabolene-type sesquiterpenes 1-5, including two new compounds axinysalines A (1) and B (2). The structures of new compounds were elucidated by analysis of high resolution (HR)-MS and two dimensional (2D)-NMR spectra and comparison of its NMR data with those of known analogues. Compound 1 exhibited moderate to weak cytotoxicity against Molt 4 and K562 cancer cell lines.
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Halichonic Acid B, a Rearranged Nitrogenous Bisabolene-Type Sesquiterpene from a Marine Sponge Axinyssa sp.
Chem Pharm Bull (Tokyo)
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Graduate School of Pharmaceutical Sciences, Kumamoto University.
A new rearranged nitrogenous bisabolone-type sesquiterpene, halichonic acid B (1), was isolated from a marine sponge Axinyssa sp. together with halichonic acid (2) and (6R,7S)-7-amino-7,8-dihydro-α-bisabolene (3). The structure of 1 was determined by extensive NMR and MS analyses, revealing an unprecedented carbon framework, and its absolute configuration was elucidated by time-dependent density-functional theory (TDDFT)-based electronic circular dichroism (ECD) spectrum calculation.
View Article and Find Full Text PDFNew nitrogenous bisabolene-type sesquiterpenes from a formosan sponge Axinyssa sp.
Chem Pharm Bull (Tokyo)
May 2015
Department of Biotechnology, Kaohsiung Medical University.
Chemical investigation of a Formosan sponge Axinyssa sp. has led to the isolation of five nitrogenous bisabolene-type sesquiterpenes 1-5, including two new compounds axinysalines A (1) and B (2). The structures of new compounds were elucidated by analysis of high resolution (HR)-MS and two dimensional (2D)-NMR spectra and comparison of its NMR data with those of known analogues.
View Article and Find Full Text PDFNew nitrogenous bisabolene-type sesquiterpenes from a micronesian marine sponge, axinyssa species.
J Nat Prod
September 1999
Department of Chemistry and Biochemistry, The University of Oklahoma, Norman, Oklahoma 73019-0370, and Marine Ecology and Aquaculture Group, National Institute of Water and Atmospheric Research, Ltd., Newmarket, Auckland, New Zealand.
Chemical investigation of an Axinyssa species of sponge collected at Yap Island afforded three new nitrogenous sesquiterpenes, 1-3, together with the known compound 3-formamidotheonellin (4). The structures of compounds 1, 3, and 4 were confirmed by spectroscopic methods, and compound 2 was tentatively identified by comparison of its (1)H and (13)C NMR data with those of 1, 3, and 4 and (1)H decoupling experiments.
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