AI Article Synopsis
- The study explored the effectiveness of mixed micelles containing PEG-PE, vitamin E, curcumin, and paclitaxel against both regular and drug-resistant SK-OV-3 human ovarian cancer cells.
- Although curcumin did not significantly boost paclitaxel's effectiveness on regular cancer cells in lab tests, a strong synergistic effect was noted against the drug-resistant version.
- In live subjects, the combined treatment led to a three-fold reduction in tumor growth for both cell types, suggesting the potential for these mixed micelles in overcoming challenges in treating resistant ovarian cancer.
Article Abstract
The therapeutic potential of mixed micelles, made of PEG-PE and vitamin E co-loaded with curcumin and paclitaxel, was investigated against SK-OV-3 human ovarian adenocarcinoma along with its multi-drug resistant version SK-OV-3-paclitaxel-resistant (TR) cells in vitro and in vivo. The addition of curcumin at various concentrations did not significantly enhance the cytotoxicity of paclitaxel against SK-OV-3 in vitro. However, a clear synergistic effect was observed with the combination treatment against SK-OV-3TR in vitro. In vivo, this combination treatment produced a three-fold tumor inhibition with each of these cell lines. Our results indicate that such co-loaded mixed micelles could have significant clinical advantages for the treatment of resistant ovarian cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3980878 | PMC |
| http://dx.doi.org/10.1016/j.ijpharm.2014.01.009 | DOI Listing |
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