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The rise, fall, and resurgence of phage therapy for urinary tract infection.
EcoSal Plus
December 2024
Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA.
In the face of rising antimicrobial resistance, bacteriophage therapy, also known as phage therapy, is seeing a resurgence as a potential treatment for bacterial infections including urinary tract infection (UTI). Primarily caused by uropathogenic , the 400 million UTI cases annually are major global healthcare burdens and a primary cause of antibiotic prescriptions in the outpatient setting. Phage therapy has several potential advantages over antibiotics including the ability to disrupt bacterial biofilms and synergize with antimicrobial treatments with minimal side effects or impacts on the microbiota.
View Article and Find Full Text PDFThe asymptomatic bacteriuria in the patients with epilepsy: A cross-sectional study.
Heliyon
December 2024
Department of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Background: Epilepsy is a chronic neurological disorder characterized by repetitive unprovoked seizures. While certain anti-seizure medications have been linked to urinary tract infections, limited information exists on the occurrence and risk factors of asymptomatic bacteriuria (ASB) in individuals with epilepsy. This study aims to investigate the prevalence and factors associated with ASB in patients with epilepsy.
View Article and Find Full Text PDFBackground: Improved access to quality antenatal care (ANC) promotes healthy behaviors and early complication management, enhancing maternal and newborn outcomes. The Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health (ENAT) intervention in Ethiopia aimed to increase newborn birth weight by improving ANC utilization and quality. ENAT task shared and decentralized ANC services to facilitate early contact and point of care (POC) testing and management of maternal infections and anemia.
View Article and Find Full Text PDFAssociation between hyponatremia and disease severity in pediatric urinary tract infections.
BMC Pediatr
November 2024
Department of Pediatrics, Chi Mei Medicine Center, No. 901, Zhonghua Road., Yongkang Dist, Tainan City, 710402, Taiwan.
Article Synopsis
- Acute urinary tract infections (UTIs) are common in children, affecting about 8% of girls and 2% of boys by age 7, with serious cases leading to acute pyelonephritis (APN).
- A study reviewed data from 344 pediatric UTI/APN patients treated from 2012 to 2022, categorizing them by serum sodium levels (hyponatremia vs. eunatremia).
- Results showed that patients with hyponatremia had higher instances of APN and abnormal kidney scans, suggesting hyponatremia might indicate a more severe UTI, although further research is needed to understand its implications.
Prevalence of bacteriuria and bacterial resistance in adolescents from the center of the state of Tlaxcala, Mexico.
Bol Med Hosp Infant Mex
November 2024
Unidad de Investigación en Nefrología y Metabolismo Mineral Óseo, Hospital Infantil de México Federico Gómez, Mexico City.
Article Synopsis
- Urinary tract infections and bacteriuria are prevalent among adolescents, with rising antibiotic resistance posing a significant health risk.
- A study in Tlaxcala, Mexico, involved 905 adolescents aged 11 to 18 and found a bacteriuria prevalence of 3.4%, primarily affecting asymptomatic individuals.
- Escherichia coli was the most common pathogen identified, with notable resistance to antibiotics, and risk factors included being female, sexually active, using contraceptives, and consuming sweetened drinks.
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