The blockade of the Ca++ influx increased the postdenervation depolarization of the membrane potential in rat diaphragm muscle fibres, while elevation of the intracellular Ca++ content by caffeine hyperpolarized the muscle membrane. Direct electrical stimulation of muscle or application of carbamylcholine reduced the degree of postdenervation membrane depolarization. Verapamil and d-tubocurarine abolished the hyperpolarizing effect of the electrical stimulation. The hyperpolarizing effects of carbamylcholine and electrical stimulation were not added. It is suggested that the influx of the extracellular Ca++ through acetylcholine-sensitive ionic channels in the external muscle membrane contributes to the neurotrophic regulation of the membrane potential in rat muscle fibres.
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