AI Article Synopsis
- A synthetic method was developed to create 3-hydroxymethyl-5-(1H-1,2,3-triazol)isoxazolidines using a cycloaddition reaction with microwave heating.
- The new compounds were tested for their biological activity and found to inhibit the growth of certain human thyroid cancer cell lines, with effectiveness measured by IC50 values between 3.87 and 8.76 µM.
- Results indicated that these compounds trigger cell death mechanisms like caspase-3 activation and DNA fragmentation, particularly in follicular thyroid cancer cells.
Article Abstract
A synthetic approach towards a series of 3-hydroxymethyl-5-(1H-1,2,3-triazol)isoxazolidines has been reported, according to a procedure based on the cycloaddition reaction, under microwave irradiation, of a nitrone with 1-vinyl triazoles, prepared by a click reaction of azides with alkynes. Biological tests show that the synthesized compounds are able to inhibit proliferation of follicular and anaplastic human thyroid cancer cell lines, with IC50 values ranging from 3.87 to 8.76 lM. The obtained compounds induce caspase-3 activation and DNA fragmentation prevalently in follicular human thyroid cancer cell lines.
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| http://dx.doi.org/10.1016/j.bmc.2013.10.001 | DOI Listing |
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