Purpose: This study explored the substance abuse and human immunodeficiency virus prevention needs of urban minority adolescents.
Design: Six 1-hour focus groups.
Setting: Two high schools and two community-based organizations located in the city of Paterson, New Jersey.
Participants: The sample included 41 African-American and Latino youth, ranging in ages from 13 to 18 years.
Method: Data were collected through six focus group interviews. Each group discussion was audio-recorded and transcribed. Qualitative software was then used to facilitate the processes of thematic analysis, until emergent themes transcended the data. To bolster the rigor and confirmability of analysis, additional researchers coded stratified selections of transcript.
Results: Study participants were able to identify the environmental threats and structural deficits impacting their city. Few of the youth were able to recognize substance abuse and HIV/AIDS prevention messages in their immediate surroundings. Additionally, most participants indicated that prevention messages must be delivered in authentic ways from relatable sources in order to resonate with their audience.
Conclusion: Our findings emphasize the importance of infusing the adolescents' voices into the design and implementation of health promotion messages, which could serve to increase their receptivity and responsiveness, and the overall resonance of the interventions.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.4278/ajhp.130117-QUAL-34 | DOI Listing |
NEJM Evid
February 2025
DURECT Corporation, Cupertino, CA.
Background: Larsucosterol is a DNA methyltransferase inhibitor in development for alcohol-associated hepatitis (AH), a disease for which there is no approved therapy.
Methods: In this phase 2b trial, patients with severe AH were randomly assigned 1:1:1 to receive 30 mg or 90 mg of larsucosterol or placebo; a second dose was administered after 72 hours if the patient remained hospitalized. All patients received supportive care as determined by investigators.
Background: Pulmonary Langerhans Cell Histiocytosis (PLCH) is a rare interstitial lung disease primarily affecting young to middle-aged smokers. While traditionally linked to tobacco use, there is growing evidence that cannabis use may contribute to PLCH.
Methods: We present a case of a 52-year-old male with PLCH associated with heavy cannabis use.
Perioper Med (Lond)
January 2025
Department of Nursing, School of Nursing and Midwifery, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Background: The unfamiliar atmosphere of the operating room, waiting for anesthesia, and the process of surgery and anesthesia are some of the factors causing fear and anxiety in patients. It leads to physical and psychological pressure on patients. Better understanding of patients' feelings, beliefs, or fears and recording their experiences for optimal care after surgery is helpful.
View Article and Find Full Text PDFJ Med Chem
January 2025
State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun 130062, China.
To date, the abuse of antibiotics and a gradual decline in novel antibiotic discovery enlarge the threat of drug-resistant bacterial infections, especially methicillin-resistant (MRSA). Herein, inspired by the unique structures and antibacterial activities of 2-quinolones, a class of novel 2-quinolones with substituted pyridines was synthesized. Notably, compound , the derivative with a methylpyridine fragment, showed potent antibacterial and antibiofilm activities, especially for MRSA strains (MIC = 0.
View Article and Find Full Text PDFElife
January 2025
Department of Pharmaceutical Sciences, University of Kentucky, Lexington, United States.
Reversing opioid overdoses in rats using a drug that does not enter the brain prevents the sudden and severe withdrawal symptoms associated with therapeutics that target the central nervous system.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!