A method for the coupling of organozinc reagents, difluorocarbene, and allylic electrophiles is described. The reaction involves insertion of difluorocarbene into the carbon-zinc bond followed by copper-catalyzed allylic substitution.

Download full-text PDF

Source
http://dx.doi.org/10.1021/jo4024705DOI Listing

Publication Analysis

Top Keywords

organozinc reagents
8
copper-catalyzed allylation
4
allylation αα-difluoro-substituted
4
αα-difluoro-substituted organozinc
4
reagents method
4
method coupling
4
coupling organozinc
4
reagents difluorocarbene
4
difluorocarbene allylic
4
allylic electrophiles
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!