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Light-responsive micelles of spiropyran initiated hyperbranched polyglycerol for smart drug delivery. | LitMetric

Light-responsive micelles of spiropyran initiated hyperbranched polyglycerol for smart drug delivery.

Biomacromolecules

Department of Chemistry and Interdisciplinary School of Green Energy, Ulsan National Institute of Science and Technology (UNIST), Ulsan 689-798, Korea.

Published: February 2014

AI Article Synopsis

  • Light-responsive polymeric micelles, using the photochromic molecule Spiropyran (SP), enable controlled drug delivery by switching between hydrophobic and hydrophilic states with light exposure.* -
  • The successful assembly and disassembly of these micelles were confirmed through various techniques, including electron microscopy and spectroscopy, showing their effectiveness for drug delivery.* -
  • The micelles demonstrated high biocompatibility in cell tests, indicating their potential for use in advanced smart drug delivery systems for medical applications.*

Article Abstract

Light-responsive polymeric micelles have emerged as site-specific and time-controlled systems for advanced drug delivery. Spiropyran (SP), a well-known photochromic molecule, was used to initiate the ring-opening multibranching polymerization of glycidol to afford a series of hyperbranched polyglycerols (SP-hb-PG). The micelle assembly and disassembly were induced by an external light source owing to the reversible photoisomerization of hydrophobic SP to hydrophilic merocyanine (MC). Transmission electron microscopy, atomic force microscopy, UV/vis spectroscopy, and dynamic light scattering demonstrated the successful assembly and disassembly of SP-hb-PG micelles. In addition, the critical micelle concentration (CMC) was determined through the fluorescence analysis of pyrene to confirm the amphiphilicity of respective SP-hb-PGn (n = 15, 29, and 36) micelles, with CMC values ranging from 13 to 20 mg/L, which is correlated to the length of the polar polyglycerol backbone. Moreover, the superior biocompatibility of the prepared SP-hb-PG was evaluated using WI-38 cells and HeLa cells, suggesting the prospective applicability of the micelles in smart drug delivery systems.

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Source
http://dx.doi.org/10.1021/bm401670tDOI Listing

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