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Postoperative serum hyperamylasemia (POH) predicts additional morbidity after pancreatoduodenectomy: It is not all about pancreatic fistula.
Surgery
August 2022
Department of General and Pancreatic Surgery-The Pancreas Institute, University of Verona Hospital Trust, Verona, Italy. Electronic address:
Background: The association between postoperative serum hyperamylasaemia (POH) and morbidity has been hypothesized but rarely explored once occurring with or without (POH-exclusive) a combined postoperative pancreatic fistula (POPF).
Methods: Analysis of patients who consecutively underwent pancreaticoduodenectomy from 2016 to 2020. POH was defined as serum amylase activity greater than the institutional upper limit of normal (52 U/L), persisting within the first 48 hours postoperatively (postoperative day [POD] 1 and 2).
Potential Roles of α-amylase in Alzheimer's Disease: Biomarker and Drug Target.
Curr Neuropharmacol
July 2022
School of Science, Monash University Malaysia, 47500 Bandar Sunway, Selangor, Malaysia.
Alzheimer's disease (AD), the most common form of dementia, is pathologically characterized by the deposition of amyloid-β plaques and the formation of neurofibrillary tangles. In a neurodegenerative brain, glucose metabolism is also impaired and considered as one of the key features in AD patients. The impairment causes a reduction in glucose transporters and the uptake of glucose as well as alterations in the specific activity of glycolytic enzymes.
View Article and Find Full Text PDFSpuriously raised serum amylase in a five-year-old girl: a note of caution in paediatric blood sampling.
Scott Med J
November 2019
Consultant Paediatric Surgeon, Department of Surgical Paediatrics, Royal Hospital for Children Glasgow, Glasgow, UK.
Introduction: Capillary (finger prick) blood sampling is commonplace in paediatric practice but this method is prone to produce spurious laboratory results.
Case Presentation: A five-year-old girl presented with abdominal pain, epigastric tenderness, tachycardia and reduced oxygen saturation. A venous blood sample haemolysed, and serum amylase on a finger prick sample was reported as 2831 units/L.
Which Mechanism is Effective on the Hyperamylasaemia After Coronary Artery Bypass Surgery?
Heart Lung Circ
May 2017
Dokuz Eylül University Faculty of Medicine, Department of Cardiovascular Surgery, İzmir, Turkey.
Background And Aim: Acute pancreatitis is one of the less frequently diagnosed lethal abdominal complications of cardiac surgery. The incidence of early postoperative period hyperamylasaemia was reported to be 30-70% of patients who underwent coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB). The mechanism of pancreatic enzyme elevation after cardiac surgery is not clear.
View Article and Find Full Text PDFA multidisciplinary approach to an unusual cause of hyperamylasaemia.
BMJ Case Rep
July 2015
Royal Infirmary of Edinburgh, Edinburgh, UK.
Clinical features together with elevation of pancreatic enzymes are the key diagnostic indicators of acute pancreatitis. We report a case of a woman in her 50s who presented with abdominal distension and serum amylase raised to more than 30 times the upper limit of normal. She was initially treated for acute pancreatitis, however, she was not symptomatic of this and the pancreas appeared to be normal on CT scan.
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