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| http://dx.doi.org/10.1007/s13193-013-0226-y | DOI Listing |
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Knee Desmoplastic Melanoma, an Uncommon Tumor, Disguised as a Malignant Peripheral Nerve Sheath Tumor: A Case Report and Review of the Literature.
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Desmoplastic melanoma is a rare and distinct subtype of cutaneous melanoma, it presents diagnostic challenges due to the lack of specific clinical features and overlapping histopathological characteristics with other malignancies, which necessitate careful clinicopathological correlation and advanced immunohistochemical profiling. While surgical excision remains the cornerstone of treatment, advances in precision medicine, particularly immune checkpoint inhibitors, have shown promise in improving outcomes for unresectable and metastatic desmoplastic melanoma. We present a case study involving a 52-year-old woman misdiagnosed with a malignant peripheral nerve sheath tumor and later identified as desmoplastic melanoma through re-evaluation of histopathological and immunohistochemical findings.
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Department of Geriatric Medicine, Affiliated Hospital of Qingdao University, Qingdao, China.
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Introduction: Large melanomas, while relatively uncommon, present significant diagnostic challenges due to their size and potential to mimic other malignancies, leading to delays in appropriate treatment. Initial misdiagnosis is a substantial concern, impacting patient outcomes. This case highlights the importance of immunohistochemistry in cancer diagnosis, and of appropriate therapeutic management, which here included excision surgery of the tumor mass.
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Special histologic subtypes of breast cancer (BC) exhibit unique phenotypes and molecular profiles with diagnostic and therapeutic implications, often differing in behavior and clinical trajectory from common BC forms. Novel methodologies, such as artificial intelligence may improve classification. Genetic predisposition plays roles in a subset of cases.
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causes life-threatening infections in immunocompromised hosts, including hospitalized neonates. This pathogen is intrinsically resistant to fluconazole, while uncommon strains resistant to multiple antifungal drugs, including voriconazole, amphotericin B, and echinocandins, have also been reported from healthcare environments. Thus, understanding how spread, persist, and adapt to healthcare settings could help us develop better infection management strategies.
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