Malignant catarrhal fever (MCF) is a fatal lymphoproliferative disease affecting bovids, cervids and other ruminant species caused by viruses belonging to subfamily Gammaherpesvirinae, genus Macavirus. Among the 10 MCF viruses known to cause the disease, alcelaphine herpesvirus 1 (AlHV-1) and ovine herpesvirus 2 (OvHV-2) are the two most widely prevalent causative organisms. The AlHV-1 naturally infects wildebeest and causes wildebeest associated MCF (WA-MCF) in cattle in regions of African sub-continent. The OvHV-2 is prevalent in all varieties of domestic sheep as a sub-clinical infection and causes sheep associated MCF (SA-MCF) in susceptible ruminants in most regions of the world. In India, the detection of cases of SA-MCF in cattle and OvHV-2 infection in sheep during the last decade has established the presence of the virus in native sheep of the country. The present review presents up to date information on various aspects of SA-MCF and its causative agent OvHV-2 with special reference to Indian scenario.
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http://dx.doi.org/10.1007/s13337-013-0163-y | DOI Listing |
Pathogens
December 2024
Department of Biochemistry, National Veterinary Research Institute, 24-100 Pulawy, Poland.
Small ruminant lentiviruses (SRLVs) infect sheep, causing a multiorganic disease called maedi-visna or ovine progressive pneumonia, which significantly affects the production and welfare of sheep, generating serious economic losses. Although not all infected animals develop fully symptomatic disease, they constantly spread the virus in the flock. Since the infection is incurable and no vaccine is available, another approach is necessary to control SRLV infections.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
College of Animal Science and Technology, Hebei Agricultural University, Baoding 071000, China.
High concentrations of prolactin (PRL)-induced ovine ovarian granulosa cell (GCs) apoptosis and could aggravate the induced effect. However, the molecular mechanisms that -induced GC apoptosis and repressed steroid hormone secretion remain unclear. In this study, GCs in the P group (GCs with high PRL concentration: 500 ng/mL PRL) and P-10 group (GCs with 500 ng/mL PRL infected by lentiviruses carrying overexpressed sequences of ) were collected for whole-transcriptome analysis.
View Article and Find Full Text PDFMicroorganisms
January 2025
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China.
With the growing demand for sheep, the sheep farming industry has developed rapidly. However, lamb diarrhea, a disease with high mortality rates, significantly hampers the industry's growth. Traditional antibiotic treatments often disrupt the Intestinal microbiota, induce antibiotic resistance, and cause adverse side effects, highlighting the urgent need to develop alternative therapies.
View Article and Find Full Text PDFGenes (Basel)
January 2025
Department of Animal, Veterinary and Food Science, University of Idaho, Moscow, ID 83844, USA.
Background: Lamb health is crucial for producers; however, the percentage of lambs that die before weaning is still 15-20%. One factor that can contribute to lamb deaths is congenital diseases. A novel semi-lethal disease has been identified in newborn Polypay lambs and termed dozer lamb syndrome.
View Article and Find Full Text PDFAnimals (Basel)
January 2025
The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot 010021, China.
Fatty acids (FAs) are a group of organic compounds that are regulated by polygenic and environmental factors and affect the taste, nutritional value, and quality of meat. Lamb meat is rich in FAs required by the human body, which has directed more attention to sheep research and meat production. The fatty acid-binding protein 4 () gene is considered a candidate gene that can affect FA composition in livestock.
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