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Advancing forecasting capabilities: A contrastive learning model for forecasting tropical cyclone rapid intensification.
Proc Natl Acad Sci U S A
January 2025
Key Laboratory of Ocean Observation and Forecasting, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266000, China.
Tropical cyclones (TCs), particularly those that rapidly intensify (RI), pose a significant threat due to the uncertainty in forecasting them. RI TC periods, which intensify by at least 13 m/s within 24 h, remain challenging to forecast accurately. Existing models achieve a probability of detection (POD) of 82.
View Article and Find Full Text PDFInfluence of Cell Physiological Status on the Intensified Fed-Batch Cultures at Ultra-High Seeding Density.
Biotechnol Appl Biochem
January 2025
The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China.
Recent years, intensified fed-batch culture with ultra-high seeding density (uHSD-IFB) is coming to the forefront of manufacturers' choice for its enhanced productivity. However, the effects of seed cell physiological state and aeration strategies on these processes remain underexplored due to the ultra-high seeding density. Currently, the pre-production seeding inoculum (N-1) crucial for the uHSD-IFB cultures relies heavily upon case-by-case empirical experiences.
View Article and Find Full Text PDF« Augmented radiotherapy » in the management of high-risk prostate cancer (PCa): a systematic review.
Crit Rev Oncol Hematol
January 2025
Centre de Radiothérapie Charlebourg, La Défense, Groupe Amethyst, 65, avenue Foch, 92250 La Garenne-Colombes, France; Department of radiation oncology, Institut Bergonié, Bordeaux, France.
Background: In patients with high-risk (HR) prostate cancer (PCa) treated with radiotherapy and androgen deprivation therapy (ADT), intensification with androgen receptor pathway inhibitor (ARPI) improves overall survival (OS), at the cost of significant side-effects. We hypothesized that "augmented RT" schedules (defined as either dose-escalation on the prostate gland over 78Gy and/or addition of whole pelvic radiotherapy (WPRT)), combined with long-term ADT can reach excellent prostate cancer specific survival (PCSS) in this population with little detrimental impact on quality of life.
Methods: We searched Pubmed database until February 8, 2024.
Continuous Production of Influenza VLPs Using IC-BEVS and Multi-Stage Bioreactors.
Biotechnol Bioeng
January 2025
Instituto de Biologia Experimental e Tecnológica (iBET), Oeiras, Portugal.
The insect cell-baculovirus expression vector system (IC-BEVS) has been an asset to produce biologics for over 30 years. With the current trend in biotechnology shifting toward process intensification and integration, developing intensified processes such as continuous production is crucial to hold this platform as a suitable alternative to others. However, the implementation of continuous production has been hindered by the lytic nature of this expression system and the process-detrimental virus passage effect.
View Article and Find Full Text PDFBiomarker-Directed Radiotherapy in Breast Cancer: A Narrative Review.
JAMA Oncol
January 2025
Department of Radiation Oncology, Iridium Netwerk, Wilrijk-Antwerp, Belgium.
Importance: Integration of molecular biomarker information into systemic therapy has become standard practice in breast cancer care. However, its implementation in guiding radiotherapy (RT) is slower. Although postoperative RT is recommended for most patients after breast-conserving surgery and, depending on risk factors, following mastectomy, emerging evidence has indicated that patients with low scores on gene expression signatures or selected clinical-pathological features may have very low local recurrence rates.
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