Syringocystadenocarcinoma papilliferum with intraepidermal pagetoid spread on an unusual location.

Am J Dermatopathol

*Ackerman Academy of Dermatopathology, New York, NY †Department of Dermatology, Affiliated Hospital of Tianjin Academy of Traditional Chinese Medicine, Tianjin, China ‡Department of Dermatopathology, Shandong Provincial Institute of Dermatology and Venereology, Jinan, China.

Published: December 2014

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http://dx.doi.org/10.1097/DAD.0000000000000046DOI Listing

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Introduction: Syringocystadenocarcinoma papilliferum is an extremely rare malignant adnexal tumor that typically arises from a papilliferous syringocystadenoma (World Health Organization classification of skin tumors, 2018.). This tumor predominantly occurs in the cephalic region.

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Article Synopsis
  • Syringocystadenoma papilliferum is a rare, harmless skin growth that can be found on the scalp and is often linked to a type of birthmark.
  • A teenage girl had a different type of skin cancer on her toe that came back after being removed twice without testing.
  • The tests (or biopsy) showed that it might be a syringocystadenoma papilliferum but also raised worries about a more aggressive cancer, stressing the need for testing when doctors remove strange growths.
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Article Synopsis
  • Syringocystadenocarcinoma papilliferum (SCACP) is a rare and aggressive cancer originating from skin appendage glands, often linked to previous skin conditions like syringocystadenoma papilliferum or nevus sebaceus.
  • A systematic review analyzed 78 case studies from 1980 to 2024, focusing on clinical features, diagnosis, treatments, and outcomes of SCACP, which commonly affects older adults and presents as ulcerated nodules on the scalp.
  • The study emphasizes the importance of surgical treatment, particularly Mohs micrographic surgery, and suggests more research into standardized treatment protocols and targeted therapies to better improve patient outcomes and understanding of its relationships with other skin conditions.
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