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The Women's Healthy Ageing Project: fertile ground for investigation of healthy participants 'at risk' for dementia. | LitMetric

AI Article Synopsis

  • Alzheimer's disease shows neuropathological changes long before clinical symptoms appear, indicating that early intervention is key to preventing cognitive decline.
  • The Women’s Healthy Aging Project (WHAP) studies over 400 Australian women to identify mid-life risk factors for late-life cognitive issues and aims to improve early detection of dementia.
  • This study uniquely combines a detailed neuropsychological assessment with extensive long-term data, including clinical measures and biological samples, to enhance understanding of dementia risk and progression.

Article Abstract

Alzheimer's disease neuropathology (amyloid, tauopathies) and brain atrophy are present decades prior to manifestation of clinical symptoms. With the failure of treatment trials it is becoming clearer that the window for prevention and therapeutic intervention is before significant neuronal loss and clinical deterioration of cognition has occurred. Early identification of those at risk of disease and optimizing their management to prevent disease in later life are crucial to delaying disease onset and improving people's quality of life. The Women's Healthy Aging Project (WHAP) is a longitudinal study of over 400 Australian-born women, epidemiologically randomly sampled in 1990. The WHAP aims to identify modifiable mid-life risk factors for the development of late-life cognitive decline, improve the understanding of the pathogenesis of dementia, and target early disease identification utilizing clinical, biomarker and health risk profiles. These aims are fortified by the ability to leverage the considerable database on health, lifestyle and socio-demographics collected prospectively from 1990 to date. This is the first study with a comprehensive neuropsychological battery, over a decade of cognitive follow-up, with all participants being offered amyloid imaging from 2012, and prospective longitudinal data including clinical and physical measures and bio-bank samples from over 20 years prior.

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Source
http://dx.doi.org/10.3109/09540261.2013.873394DOI Listing

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