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Modulates mRNA Expression of Through Multiple Signaling Pathways Related to Glycolysis in GT1-7 Cells.
Animals (Basel)
January 2025
School of Agriculture and Biology, Liaocheng University, Liaocheng 252059, China.
and miRNA regulate mammalian pubertal initiation and Gonadotropin-releasing hormone (GnRH) production. However, it remains unclear which signaling pathways regulates to modulate GnRH production. In this study, the mRNA expression levels of and in the pubertal and juvenile goat hypothalamus and pituitary gland were detected, and expression in the pubertal hypothalamus decreased significantly compared with that in juvenile tissues.
View Article and Find Full Text PDFConjugated Linoleic Acid (CLA) Mitigates High-Fat Diet (HFD)-Induced Mammary Gland Development Impairment of Pubertal Mice via Regulating CD36 Palmitoylation and Downstream JNK-ERK Pathway.
J Agric Food Chem
January 2025
Guangdong Provincial Key Laboratory of Animal Nutrition Control, National Engineering Research Center for Breeding Swine Industry and State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science, South China Agricultural University, Guangzhou 510642, P. R. China.
Conjugated linoleic acid (CLA) is known for antiobesity. However, the role of CLA in regulating high-fat diet (HFD)-impaired pubertal mammary gland development remains undefined. Here, pubertal female mice and HC11 cells were treated with HFD or palmitic acid (PA), supplemented with or without CLA, respectively.
View Article and Find Full Text PDFAssociations of linear growth with body composition of perinatally HIV-infected African adolescents.
Br J Nutr
December 2024
Institute of Child Health, University College London, London, UK.
The prevalence of poor linear growth among African children with perinatally acquired HIV remains high. There is concern that poor linear growth may to lead to later total and central fat deposition and associated non-communicable disease risks. We investigated associations between height-for-age score (HAZ) and total and regional fat and lean mass measured by dual-energy X-ray absorptiometry, expressed as internal population scores, among 839 Zimbabwean and Zambian perinatally HIV-infected male and female adolescents aged 11-19 years.
View Article and Find Full Text PDFGynecologic Issues in Adolescents with Developmental Delay.
Obstet Gynecol Clin North Am
December 2024
Department of Obstetrics and Gynecology, University of Michigan, L4113 UH South, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA; Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Gynecologic care of adolescents with developmental delay (DD) can be challenging. Teens with DD are often seen as asexual and their needs are often not met. The teen and their caregivers need a holistic approach from their providers by addressing all reproductive health needs, including period management, education, sexuality, safety, possible abuse, preventive care, and contraception.
View Article and Find Full Text PDFTiming of puberty suppression in transgender adolescents and sexual functioning after vaginoplasty.
J Sex Med
January 2025
Center of Expertise on Gender Dysphoria, Amsterdam University Medical Center, Amsterdam, 1007, The Netherlands.
Background: Sexual function in transgender adolescents after puberty suppression has been a topic of recent clinical and scientific questions.
Aim: This study aimed to explore the long-term effects of early treatment with puberty suppression on sexual functioning of transfeminine individuals after vaginoplasty.
Methods: This retrospective cohort study included 37 transfeminine individuals treated with a gonadotropin-releasing hormone agonist (puberty suppression), estrogen, and vaginoplasty (penile inversion technique or intestinal vaginoplasty) at the Center of Expertise on Gender Dysphoria in Amsterdam, the Netherlands, between 2000 and 2016.
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