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Elucidating stearoyl metabolism and NCOA4-mediated ferroptosis in gastric cancer liver metastasis through multi-omics single-cell integrative mendelian analysis: advancing personalized immunotherapy strategies.
Discov Oncol
January 2025
Western Institute of Digital-Intelligent Medicine, 401329, Chongqing, China.
Background: The metabolism of stearoyl-GPE plays a key role in the liver metastasis of gastric cancer. This investigation delves into the mechanisms underlying the intricate tumor microenvironment (TME) heterogeneity triggered by stearoyl metabolism in gastric cancer with liver metastasis (LMGC), offering novel perspectives for LMGC.
Objective: Utilizing Mendelian randomization, we determined that stearoyl metabolism significantly contributes to the progression of gastric cancer (GC).
Advances in breeding for enhanced iron and zinc concentration in common bean in Eastern Africa.
J Exp Bot
January 2025
Dept. of Plant Science and Crop Protection, University of Nairobi, P.O Box 29053-00625, Nairobi, Kenya.
Micronutrient malnutrition is one of the most serious health challenges facing vast sectors of Africa's population particularly resource-poor women and children. Main deficiencies include iron, zinc and vitamin A. Plant breeding has frequently been advocated as the most sustainable strategy of providing varieties of different food crop species with enhanced micronutrient density to combat the global hidden hunger problem which affects more than 2 billion people.
View Article and Find Full Text PDFImproved Diet Quality in Elite and Entry-Level Military Women Compared With Civilian-Matched Counterparts.
Curr Dev Nutr
January 2025
United States Army Research Institute of Environmental Medicine (USARIEM), Military Performance Division, Natick, MA, United States.
Background: Dietary intake is a modifiable factor linked to short-term and long-term health. The Healthy Eating Index (HEI) is an objective measure to assess diet quality and population-level comparisons, like military to civilian.
Objectives: This study aimed to characterize diet quality of early-career and mid-career female soldiers compared with that of age-matches and sex-matched civilians and to link indicators of cardiometabolic disease risk to dietary outcomes and health status.
In Silico Subtractive Proteome Analysis to Design Multi-Epitope-Based Subunit Vaccine against .
J Microbiol Biotechnol
November 2024
Fatemah AlMalki, Biology Department, College of Science and Humanities- Al Quwaiiyah, Shaqra University, Al Quwaiiyah 19257, Saudi Arabia.
is a gram-negative, facultatively anaerobic bacterium typically found in the oropharynx and respiratory tract of humans. It is responsible for various infections, including head-and-neck infections, pericarditis, and abscesses of the deltoid, perirenal tissue, brain, and liver. Increasing antibiotic resistance requires urgent identification of novel drug targets to fight this bacterium.
View Article and Find Full Text PDFDual ferroptosis induction in N2-TANs and TNBC cells via FTH1 targeting: A therapeutic strategy for triple-negative breast cancer.
Cell Rep Med
January 2025
Shanghai Frontiers Science Center of TCM Chemical Biology, Institute of Interdisciplinary Integrative Medicine Research and Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:
Tumor-associated neutrophils (TANs) play a critical role in the progression and prognosis of triple-negative breast cancer (TNBC), with N2-type TANs known for their pro-tumor characteristics. This study introduces CT-1, a derivative of cryptotanshinone that effectively suppresses TNBC growth while selectively reducing the proportion of N2-type TANs within tumor tissue. Notably, CT-1 induces simultaneous ferroptosis in both N2-type TANs and TNBC cells, a dual mechanism that enhances its therapeutic efficacy.
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