This monthly feature will help readers keep current on new drugs, new indications, dosage forms, and safety-related changes in labeling or use. Efforts have been made to ensure the accuracy of this information; however, if there are any questions, please let me know at bakerdan@wsu.edu.
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| http://dx.doi.org/10.1310/hpj4807-595 | DOI Listing |
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Platform Technology in Global Vaccine Regulation: Development, Applications, and Regulatory Strategies with Insights from China.
Vaccines (Basel)
December 2024
Center for Drug Evaluation, National Medical Products Administration, Zone 2, No. 22 Guangde Street, Beijing Economic and Technological Development Zone, Beijing 100076, China.
The concept of "platform technology" gained prominence after the Ebola outbreak and since then has become essential to international vaccine (prophylactic vaccines against infectious disease) regulatory frameworks. Its significance was further amplified during the COVID-19 pandemic, where platform technology enabled the rapid development and approval of vaccines, optimizing regulatory processes, and enhancing global public health responses. As a transformative tool, platform technology streamlines product development, allowing for the reduction in the number of clinical trials or exemption from certain clinical trials and facilitating cross-referencing in regulatory submissions.
View Article and Find Full Text PDFMultifractal dynamic changes of spontaneous brain activity in psychiatric disorders: Adult attention deficit-hyperactivity disorder, bipolar disorder, and schizophrenia.
J Affect Disord
January 2025
School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, China; Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ 07102, USA. Electronic address:
It is one of the strategies to study the complexity of spontaneous fluctuation of brain neurons based on resting-state functional magnetic resonance imaging (rs-fMRI), but the multifractal characteristics of spontaneous fluctuation of brain neurons in psychiatric diseases need to be studied. Therefore, this paper will study the multifractal spontaneous brain activity changes in psychiatric disorders using the multifractal detrended fluctuation analysis algorithm based on the UCLA datasets. Specifically: (1) multifractal characteristics in adult attention deficit-hyperactivity disorder (ADHD), bipolar disorder (BP), and schizophrenia (SCHZ); (2) the source of those multifractal characteristics.
View Article and Find Full Text PDFHow does age impact understanding of epistemic adverbs in health communication?
Geriatr Nurs
January 2025
School of Psychology and Counselling, Queensland University of Technology, Brisbane, Australia.
Objective: Not much is known about how one's understanding of words may differ with age. Here we explore how epistemic adverbs - as used in health communication to indicate degrees of uncertainty and risk - are understood by older and younger monolingual speakers of Australian English.
Methods: We used an online dissimilarity rating task with sentence pairs presented as first and second doctor opinions which differed only with respect to the embedded epistemic adverbs (e.
Biglycan-driven risk stratification in ZFTA-RELA fusion supratentorial ependymomas through transcriptome profiling.
Acta Neuropathol Commun
January 2025
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
Recent genomic studies have allowed the subdivision of intracranial ependymomas into molecularly distinct groups with highly specific clinical features and outcomes. The majority of supratentorial ependymomas (ST-EPN) harbor ZFTA-RELA fusions which were designated, in general, as an intermediate risk tumor variant. However, molecular prognosticators within ST-EPN ZFTA-RELA have not been determined yet.
View Article and Find Full Text PDFTherapeutic extraction of second molars in orthodontics: a scoping review.
BMC Oral Health
January 2025
Department of Orthodontics, Faculty of Dentistry, Mansoura University, Mansoura, 35516, Egypt.
Objective: To review the literature to identify the present evidence on the extraction of second molars in orthodontics.
Materials & Method: A search of the MEDLINE/PubMed, Scopus, Web of Science™, and ProQuest databases for full-text articles was done on March 5, 2024. The search went back till the 1st of January 1991 and was limited to articles in English.
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