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Analyses of biosynthesis mutants reveal that the fifth and sixth sugars of the Porphyromonas gingivalis O-glycan are L-fucose and N-acetylgalactosamine respectively.
Gene
December 2024
Melbourne Dental School, Bio21 Institute, The University of Melbourne, Parkville, Victoria, Australia. Electronic address:
The oral pathogen, Porphyromonas gingivalis has a general O-glycosylation system which it utilises to modify hundreds of proteins localised outside of the cytoplasm. The O-glycan is a heptasaccharide that includes a putative L-fucose and N-acetylgalactosamine (GalNAc) as the 5th and 6th sugar residues respectively. The putative L-fucose is expected to be synthesized as GDP-L-fucose involving the enzymes Gmd (PGN_1078) and Fcl (PGN_1079), while GalNAc is putatively epimerised from GlcNAc by GalE (PGN_1614).
View Article and Find Full Text PDFDevelopment of monoclonal antibodies against Mfa1 and their protective capacity in an experimental periodontitis model.
mSphere
December 2024
Joint National Laboratory for Antibody Drug Engineering, School of Medicine, Henan University, Kaifeng, China.
Article Synopsis
- The text discusses the significance of the Mfa1 fimbriae protein in a gram-negative anaerobe that causes periodontitis and highlights its potential as a therapeutic target.
- The study developed monoclonal antibodies (mAbs) against Mfa1 which showed effectiveness in reducing bacterial infection and inflammation in experimental models of periodontitis.
- Results indicate that anti-Mfa1 mAbs could serve as valuable tools for both diagnosing and treating Mfa1-related infections and diseases, paving the way for improved therapeutic strategies.
From a better knowledge of periodontal disease to Porphyromonas gingivalis target for rheumatoid arthritis disease activity.
Joint Bone Spine
November 2024
Inserm, SAINBIOSE U1059, Rheumatology Departement, Mines Saint-Étienne, Université Jean-Monnet Saint-Étienne, CHU de Saint-Etienne, 42023 Saint-Étienne, France. Electronic address:
Periodontal disease (PD) and rheumatoid arthritis (RA) are both inflammatory diseases affecting the tooth and joint, with local inflammation associated with bone loss. Bacterial infections by oral bacteria are involved in periodontal inflammation, and the best known to be associated with PD is Porphyromonas gingivalis (Pg). A large body of recent data suggests a strong involvement of this specific bacteria, Pg, in PD outcomes, but also in RA.
View Article and Find Full Text PDFAnti-Porphyromonas gingivalis Antibody Levels in Patients With Stroke and Atrial Fibrillation: A Systematic Review and Meta-Analysis.
Clin Exp Dent Res
December 2024
School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Objectives: Atrial fibrillation (AF) and stroke are two highly related conditions, with periodontitis and periodontal pathogens, such as Porphyromonas gingivalis (Pg), appearing to be the most prominent common risk factors. In this study, we evaluated studies assessing Pg infection via serum/plasma anti-Pg antibodies in patients with AF and/or stroke.
Material And Methods: Online databases (PubMed, Scopus, Embase, and the Web of Science) were screened for studies showing the association between anti-Pg antibodies with stroke and/or AF.
Connecting the dots: NETosis and the periodontitis-rheumatoid arthritis nexus.
Int J Rheum Dis
November 2024
Department of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia.
Periodontitis (PD) is characterized by the host's inflammatory responses to microbial dental biofilm dysbiosis, potentially resulting in tooth loss if left untreated. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease leading to synovial inflammation and destruction of joint cartilage and bone. The suggested association between PD and RA is based on the potential of chronic inflammation present in periodontitis, which could induce alterations in proteins through post-translational modifications, leading to the formation of citrullinated and carbamylated protein antigens.
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