Tuberculosis of the thymus is very uncommon. Most previously reported cases have involved adolescents or adults. Herein, we report a case of tuberculosis of the thymus diagnosed in a 6-month-old infant, presenting with progressive dyspnea and a mediastinal mass. Both clinical and radiologic findings were nonspecific, while pathologic findings confirmed thymic tissue with massive caseous granulomas consistent with tuberculosis.
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Comparative the impact intraoperative phrenic nerve sacrifice on prognosis patients with thymoma.
BMC Pulm Med
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Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, No 9, Bei guan Street, Tong Zhou District, Beijing, 101149, P. R. China.
Objectives: Complete removal of the tumor and surrounding tissue is the most important prognostic factor such as survival after surgery. When the tumor invades the phrenic nerve, the impact of intraoperative phrenic nerve sacrifice on the short- and long-term prognosis of patients is not clear. This study aims to explore the differences in prognosis between patients with malignant thymoma with and without phrenic nerve sacrifice during surgery, as well as analyze related factors.
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- Thymomas are the most common type of tumors found in the anterior mediastinum and are derived from thymic epithelial cells, while non-tuberculous mycobacteria (NTM) are a group of bacteria not related to tuberculosis.
- A case study used targeted next-generation sequencing (tNGS) to quickly diagnose NTM infection in a patient who had recently undergone thymoma surgery, highlighting the importance of understanding lung infections following such operations.
- Post-surgery, the immune system is weakened, so if pneumonia treatments are not effective, doctors should consider the possibility of NTM infections and should utilize advanced sequencing techniques to make a timely diagnosis.
Immunohistochemistry for YAP1 N-terminus and C-terminus highlights metaplastic thymoma and high-grade thymic epithelial tumors by different staining patterns.
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Institute of Pathology, University Medical Center Göttingen, University of Göttingen, Göttingen, Germany.
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- Metaplastic thymoma (MT) is a rare type of thymic tumor that has a specific genetic fusion (YAP1::MAML2), similar to skin tumors called poromas.
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Clinical and genomic evaluations of a persistent fatal SARS-CoV-2 infection in a goods syndrome patient: a case report.
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Department of Arboviruses and Viral Hemorrhagic Fevers (National Reference Laboratory), Pasteur Institute of Iran, 69 Pasteur Ave, 1316943551, Tehran, Iran.
The coronavirus disease of 2019 (COVID-19) resulted from an infection by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) which is the main cause of acute respiratory distress syndrome (ARDS) in global population from 2019 on. It may contribute to higher rate of death among the patients with immunodeficiency based on recent reports. In addition, Good syndrome (GS) as a result of thymoma removal might cause in some long-lasting microbial infections.
View Article and Find Full Text PDFImmunopathology of Pulmonary Infection in a Humanized Mouse Model.
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Public Health Research Institute, Rutgers-New Jersey Medical School, Newark, NJ 07103, USA.
Despite the availability of antibiotic therapy, tuberculosis (TB) is prevailing as a leading killer among human infectious diseases, which highlights the need for better intervention strategies to control TB. Several animal model systems, including mice, guinea pigs, rabbits, and non-human primates have been developed and explored to understand TB pathogenesis. Although each of these models contributes to our current understanding of host- (Mtb) interactions, none of these models fully recapitulate the pathological spectrum of clinical TB seen in human patients.
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