AI Article Synopsis
- Bronchoalveolar lavage fluid (BALF) and pleural cavity lavage fluid (PLF) are effective experimental materials for evaluating lung toxicity in rats exposed to chemicals.
- Isoflurane is a safe alternative to diethyl ether for euthanasia, with no significant differences observed in BALF properties.
- Using zinc chloride as a model chemical, the study concluded that combining BALF and PLF provides a reliable approach for assessing pulmonary toxicity.
Article Abstract
Usefulness of bronchoalveolar lavage fluid (BALF) and pleural cavity lavage fluid (PLF) as an experimental material was evaluated for the assessment of pulmonary toxicity of chemicals in rats. From the viewpoint of safety, isoflurane can be used for euthanasia/anesthesia because there was no difference in biological properties of BALF between diethyl ether and isoflurane. Here, we also recognized phosphate buffered saline (PBS) and distilled water equally as a solvent/vehicle for negative control. PLF is also provided as a useful target material as well as BALF for assessing chemical lung toxicity. To evaluate the method, we used zinc chloride as a model chemical and obtained the expected and satisfied results. We may conclude that the intratracheal treatment and combination usage of BALF and PLF as a target material is a good method for assessment of chemical pulmonary (lung and plural cavity) toxicity in rats.
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| http://dx.doi.org/10.2131/jts.39.141 | DOI Listing |
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