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Hemophagocytic lymphohistiocytosis complicating erythroleukemia in a child with monosomy 7: a case report and review of the literature. | LitMetric

Hemophagocytic lymphohistiocytosis complicating erythroleukemia in a child with monosomy 7: a case report and review of the literature.

Case Rep Hematol

Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Mofid Children's Hospital, Tehran 15468-15514, Iran.

Published: January 2014

AI Article Synopsis

Article Abstract

Herein, the first case of childhood erythrophagocytosis following chemotherapy for erythroleukemia in a child with monosomy 7 is reported. A 5-year-old boy presented with anemia, thrombocytopenia, and hepatosplenomegaly in whom erythroleukemia was diagnosed. Prolonged pancytopenia accompanied by persistent fever and huge splenomegaly and hepatomegaly became evident after 2 courses of chemotherapy. On bone marrow aspiration, macrophages phagocytosing erythroid precursors were observed and the diagnosis of HLH was established; additionally, monosomy 7 was detected on bone marrow cytogenetic examination. In conclusion, monosomy 7 can lead to erythrophagocytosis associated with erythroid leukemia and should be considered among the chromosomal abnormalities contributing to the association.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876716PMC
http://dx.doi.org/10.1155/2013/581073DOI Listing

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