There is a growing body of research on Alzheimer's disease and driving, but much less is known about less common dementias, such as frontotemporal dementia (FTD). The purpose of this study was to review the empirical literature about FTD and driving. A study was included if it met the following criteria: published from 1992 to 2013 in English, research involving humans, and included both FTD and driving data. We searched the following electronic databases: EBSCOhost, PubMed, Google Scholar, Proquest, Web of Knowledge, and Publishing Connect. A total of 367 abstracts were reviewed; however, only 4 articles satisfied the inclusion criteria. Results showed that drivers with FTD had more problems than control groups. Specific driving issues were related to antisocial behaviors common among people with FTD (eg, hit and run crashes, failure to stop at red lights, speeding infractions, and failure to recognize pedestrians at intersections). More research on FTD and driving is needed.
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http://dx.doi.org/10.1177/1533317513518656 | DOI Listing |
Chembiochem
December 2024
University of Palermo: Universita degli Studi di Palermo, STEBICEF, Viale delle Scienze, ed.17, 90128, Palermo, ITALY.
The most recurrent familial cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of an abnormal number of intronic GGGGCC (G4C2) repetitions in the C9orf72 gene, which has been proposed to drive ALS/FTD pathogenesis. Recently, it has been shown that such G4C2 repetitions can fold into G-quadruplex (G4) secondary structures. These G4s have been selectively stabilized by small-molecule binders, furnishing proof of principle that targeting these non-canonical nucleic acid sequences represents a novel and effective therapeutic strategy to tackle neurodegenerative disorders.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
December 2024
Cell and Molecular Biology Department, University of Rhode Island, Kingston, RI 02881.
Alzheimers Res Ther
October 2024
Department of Medical Imaging, Radboud University Medical Center, Geert Grooteplein Zuid 10, Nijmegen, 6525 EZ, The Netherlands.
Purpose: The loss of olfactory function is known to occur in patients suffering from (behavioral variant) frontotemporal dementia ((bv)FTD) and Alzheimer's disease (AD), although different pathophysiological mechanisms underpin this clinical symptom in both disorders. This study assessed whether brain metabolism of the olfactory circuit as assessed by positron emission tomography (PET) imaging with 2-[fluorine-18]fluoro-2-deoxy-d-glucose ([F]-FDG) can distinguish these entities in different subsets of patients.
Methods: Patients presenting with cognitive decline were included from a prospectively kept database: (1) bvFTD patients, (2) AD patients and (3) patients with logopenic primary progressive aphasia (PPA).
Unlabelled: Neuronal hyperexcitability is a hallmark of amyotrophic lateral sclerosis (ALS) but its relationship with the TDP-43 aggregates that comprise the predominant pathology in over 90% of ALS cases remains unclear. Emerging evidence in tissue and slice culture models indicate that TDP-43 pathology induces neuronal hyperexcitability suggesting it may be responsible for the excitotoxicity long believed to be a major driver of ALS neuron death. Here, we characterized hyperexcitability and neurodegeneration in the hippocampus of doxycycline-regulatable rNLS8 mice (NEFH-tTA x tetO-hTDP-43ΔNLS), followed by treatment with AAV encoded DREADDs and anti-seizure medications to measure the effect on behavioral function and neurodegeneration.
View Article and Find Full Text PDFScience
October 2024
UCL Queen Square Motor Neuron Disease Centre, Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London WC1N 3BG, UK.
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