AI Article Synopsis
- - Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder leading to severe infections, with female carriers of the X-linked form typically remaining unaffected.
- - A 22-year-old pregnant woman, a known carrier of CGD, experienced chorioamnionitis in her three pregnancies, culminating in a premature delivery at 25 weeks during her third pregnancy.
- - It's crucial for healthcare providers to monitor CGD carriers closely during pregnancy and consider early prophylactic antibiotics to reduce infection risks, even if the patient shows no symptoms.
Article Abstract
Background: Chronic granulomatous disease is a primary immunodeficiency disorder characterized by severe recurrent bacterial and fungal infections. Female carriers of the X-linked form of the disorder usually are unaffected and rarely have serious infections.
Case: A 22-year-old pregnant patient known to be a carrier of the X-linked form of chronic granulomatous disease had a history of chorioamnionitis during her two previous pregnancies. During her third pregnancy, she presented again with the same diagnosis, which resulted in delivery at 25 weeks of gestation.
Conclusion: Carriers of chronic granulomatous disease should be monitored closely during pregnancy, as if they have the disease. To decrease the risk of infectious morbidity and mortality, obstetricians should have a low threshold for starting prophylactic antibiotics early during pregnancy, even if the patient is asymptomatic.
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| http://dx.doi.org/10.1097/AOG.0000000000000097 | DOI Listing |
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