Objective: Establish rate of disorders of consciousness (DOC) and course of recovery in adults who have sustained severe traumatic brain injury (sTBI).
Setting: Four Norwegian neurosurgical departments.
Participants: Vegetative or minimally conscious patients.
Design: Prospective, longitudinal population-based study of adults with sTBI with follow-ups at 3, 12, and 24-36 months postinjury.
Main Measures: Coma Recovery Scale-Revised, Glasgow Coma Scale, Extended Glasgow Outcome Scale, and Disability Rating Scale.
Results: Three months postinjury, 2% of the sTBI population remained in a vegetative or minimally conscious state, reduced by the half after 1 year, corresponding to average annual age-adjusted incidence rates of DOC of 0.09 per 100 000 3 months post-sTBI. At 3 and 12 months, the incidence was 0.06 and 0.01 per 100 000 for the vegetative state and 0.03 and 0.04 per 100 000 for the minimally conscious state. Diagnostic categorization was stable between 12 and 24-36 months, although clinically relevant improvements were observed in minimally conscious patients.
Conclusion: The data suggest that prolonged DOC is rare following sTBI in Norway, contrary to the commonly held belief that improvements in intensive care treatment have resulted in an increased incidence of DOC. Prolonged DOC was associated with severity of injury, subcortical lesions, and diffuse axonal injury.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/HTR.0000000000000017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Magnetic Resonance Imaging of Gastric Motility in Conscious Rats.
Neurogastroenterol Motil
December 2024
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Introduction: Gastrointestinal (GI) magnetic resonance imaging (MRI) enables simultaneous assessment of gastric peristalsis, emptying, and intestinal filling and transit. However, GI MRI in animals typically requires anesthesia, which complicates physiology and confounds interpretation and translation to humans. This study aimed to establish GI MRI in conscious rats, and for the first time, characterize GI motor functions in awake versus anesthetized conditions.
View Article and Find Full Text PDFRole of surgical vaginoscopy through no-touch hysteroscope in the treatment of female reproductive polyps.
BMC Surg
December 2024
2Department of Obstetrics and Gynecology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Background: The study aims to investigate the application of surgical vaginoscopy via a no-touch hysteroscopic approach for the management of female genital polyps. The primary objective is to assess the feasibility of this technique in treating intrauterine pathologies in both pregnant and non-pregnant women.
Methods: A total of forty-six patients diagnosed with genital polyps underwent operative vaginoscopy at a university-affiliated hospital between April 1, 2017 and May 31, 2023.
Centralising a loss of consciousness to the central medial thalamus.
Brain Neurosci Adv
December 2024
Department of Psychology, University of Cambridge, Cambridge, UK.
Although a role of the thalamus in different arousal and awareness states is well established, there is a surprising lack of knowledge on subregional specificity within this complex, multinucleated structure of the diencephalon. In their recent paper 'Extrasynaptic GABA-A receptors in central medial thalamus mediate anaesthesia in rats', Muheyati et al. evaluated whether GABA receptors expressed in the central medial (CM), paraventricular (PV) or lateral mediodorsal (MD) nuclei of the thalamus contribute to the loss of the righting reflex (LORR) in rats.
View Article and Find Full Text PDFMortality of chronic disorders of consciousness in adults and adolescents - a retrospective community based study from Salzburg, Austria.
Front Neurol
December 2024
Department of Neurology, Neurological Intensive Care and Neurorehabilitation, Christian Doppler Medical Centre, Centre for Cognitive Neuroscience Salzburg, Member of the European Reference Network EpiCARE, Paracelsus Medical University, Salzburg, Austria.
Introduction: Epidemiological data on disorders of consciousness (DoC) is rare and very heterogeneous due to difficulties in case ascertainment and differences in health care pathways between countries. This study reports data on mortality and survival time for DoC patients in Salzburg, Austria.
Methods: All patients with DoC were registered in the health care region of Salzburg North, Austria between 2007 and 2022 and their death data retrieved from the Statistik Austria.
Abnormal characteristics in disorders of consciousness: A resting-state functional magnetic resonance imaging study.
Brain Res
December 2024
Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China; China Rehabilitation Research Center, Beijing, China; University of Health and Rehabilitation Sciences, Qingdao, Shandong, China; Capital Medical University, Beijing, China. Electronic address:
Aims: To explore the functional brain imaging characteristics of patients with disorders of consciousness (DoC).
Methods: This prospective cohort study consecutively enrolled 27 patients in minimally conscious state (MCS), 23 in vegetative state (VS), and 25 age-matched healthy controls (HC). Resting-state functional magnetic resonance imaging (rs-fMRI) was employed to evaluate the amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), degree centrality (DC), and functional connectivity (FC).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!