The emerging role of cardiovascular MRI for risk stratification in hypertrophic cardiomyopathy.

Clin Radiol

Department of Cardiology, Heart of England NHS Foundation Trust, Birmingham, West Midlands, UK.

Published: March 2014

Hypertrophic cardiomyopathy (HCM) is the most common inheritable cardiovascular disorder. Although many HCM patients remain asymptomatic, sudden death (SD) can occur as the initial manifestation of the disease. It has been hypothesized that myocardial architectural disorganization and scarring represent an unstable electrophysiological substrate that creates susceptibility to malignant ventricular arrhythmias. Cardiovascular magnetic resonance imaging (CMR) is widely used for the diagnosis of HCM, especially in patients with an incomplete or inconclusive echocardiography study. CMR can provide precise non-invasive assessment of biventricular function, wall thickness, and assessment of myocardial fibrosis, using inversion recovery gadolinium-enhanced sequences. CMR is also one of the most promising avenues of research in HCM, and in recent years, has provided many new insights and identified a number of potential adverse prognostic indicators for SD. Future work is still needed to integrate CMR findings into traditional risk assessment algorithms. This paper reviews the evolving role of CMR for risk stratification in HCM including assessment of myocardial hypertrophy, fibrosis and ischaemia.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.crad.2013.11.012DOI Listing

Publication Analysis

Top Keywords

risk stratification
8
hypertrophic cardiomyopathy
8
hcm patients
8
assessment myocardial
8
hcm
5
cmr
5
emerging role
4
role cardiovascular
4
cardiovascular mri
4
mri risk
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!