AI Article Synopsis
- A new series of phospholipid prodrugs derived from dideoxy nucleosides has been created and tested for effectiveness against HIV.
- The study found that the biological activity increased significantly, by a factor of 500, but only for the adenine nucleoside.
- This indicates that the prodrug strategy is selective and works differently based on the specific nucleobase used.
Article Abstract
A series of α- and β-carboxylated phospholipid prodrugs of dideoxy nucleosides have been synthesized and evaluated against HIV. An increase in biological effect with a factor of 500 has only been observed for the adenine nucleoside, which suggests that this prodrug approach is base specific.
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| http://dx.doi.org/10.1016/j.bmcl.2013.12.093 | DOI Listing |
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