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Anti-microbial impact of non-antibiotic agents; salicylic acid, N-acetylcysteine, and isotretinoin against Cutibacterium acnes in patients with acne vulgaris.
Arch Dermatol Res
December 2024
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
There are two main strategies to eliminate Cutibacterium acnes and to reduce antibiotic resistance in acne treatment. The first is to target the pathogenic bacteria and the second is to change the environment for their growth. The present study aimed to evaluate the anti-microbial role of non-antibiotic agents against Cutibacterium acnes (C.
View Article and Find Full Text PDFStaphylococcus caprae and Staphylococcus epidermidis define the skin microbiome among different grades of acne vulgaris.
Arch Dermatol Res
December 2024
Faculty of Medicine, Department of Dermatology and Venereology, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Acne vulgaris (AV) has been associated with Cutibacterium acnes (C. acnes) colonization in sebaceous follicles. However, recent studies have revealed the role of skin microbiome dysbiosis in acne pathogenesis.
View Article and Find Full Text PDFDevelopment of molecular sterility assay for rapid quality release of cord blood erythrocytes units for transfusion.
Transfusion
January 2025
Transfusional Medicine Group, Vall d'Hebron Research Institute-Autonomous University of Barcelona (VHIR-UAB), Barcelona, Spain.
Background: Umbilical cord blood (CB) units stored in banks are an important source of hematopoietic stem cells for transplantation and other cell therapies. New applications, such as their use in transfusions, require rapid quality release as cord blood red blood cells (CB-RBC) have a shorter shelf life.
Study Design And Methods: This project aims to investigate the most prevalent microbial contaminants in CB preparations and validate a rapid sterility testing strategy for CB-RBC based on an automated system (BACT/ALERT®) in tandem with a molecular assay (real-time PCR) capable of detecting at least 100 CFU/mL of Cutibacterium acnes in CB-RBC to accelerate the detection of the most common slow-growing bacteria.
Orientia, Rickettsia, and the microbiome in rodent attached chiggers in North Carolina, USA.
PLoS One
December 2024
Department of Entomology and Plant Pathology, Comparative Medicine Institute, North Carolina State University, Raleigh, North Carolina, United States of America.
Chiggers are larval mites that pose a significant health risk globally via the spread of scrub typhus. However, fundamental studies into the bacterial microbiome in North America have never been considered. In this investigation, chiggers were collected in the wild from two locally common rodent host species (i.
View Article and Find Full Text PDFCutibacterium acnes periprosthetic joint infections.
Bone Joint J
December 2024
Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Article Synopsis
- - The study investigates demographics and treatment outcomes of patients with periprosthetic joint infections (PJIs) in the hip and knee, highlighting that these infections are often under-reported and can be confused with culture contamination.
- - A total of 35 PJIs were reviewed from January 2005 to December 2018, with findings indicating that about half were treated with chronic antibiotic suppression, while others underwent two-stage exchange arthroplasty; over two years, 94% remained free from revision.
- - The results showed that PJIs typically exhibited laboratory characteristics similar to traditional organisms, and infections cultured more rapidly than expected; both chronic antibiotic treatment and surgical options had low failure rates at mid-term follow-up.
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