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Making Endemic Goiter an American Disease, 1800-1820.
J Hist Med Allied Sci
September 2021
Northwest Missouri State University, Missouri, USA.
In 1800, American physician and naturalist Benjamin Smith Barton (1766-1815) published A Memoir Concerning the Disease of Goitre as it Prevails in Different Parts of North-America. The text documented the nature of the disease in the United States and highlighted how it differed from the ailment's presentation in European patients. While medical topographies were common during this period, Barton's goiter research and the steady stream of American goiter research that followed are worth special attention.
View Article and Find Full Text PDFUp to a Sign. The Insidious Effects of Energetically Inaccessible Conical Intersections on Unimolecular Reactions.
Acc Chem Res
February 2019
Department of Chemistry , Johns Hopkins University, Baltimore , Maryland 21218 , United States.
It is now well established that conical intersections play an essential role in nonadiabatic radiationless decay where their double-cone topography causes them to act as efficient funnels channeling wave packets from the upper to the lower adiabatic state. Until recently, little attention was paid to the effect of conical intersections on dynamics on the lower state, particularly when the total energy involved is significantly below that of the conical intersection seam. This energetic deficiency is routinely used as a sufficient condition to exclude consideration of excited states in ground state dynamics.
View Article and Find Full Text PDFMorphological study of upper wisdom tooth.
Rom J Morphol Embryol
January 2019
Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, Romania;
The article presents aspects of crown and root morphology of the superior wisdom teeth, aiming to several parameters: size, shape crown and occlusal surface, number, topography and orientation of the roots in order to determine which the most common morphological types are. For this purpose, the upper wisdom teeth were collected. According to studies, the dominant form of the dental crown is parallelepipedic, the rectangular or parallelogram shape of the occlusal surface has large mesial and distal-oriented sides.
View Article and Find Full Text PDFSpecificity and affinity quantification of flexible recognition from underlying energy landscape topography.
PLoS Comput Biol
August 2014
College of Physics, Jilin University, Changchun, Jilin, P. R. China; State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, P. R. China; Department of Chemistry and Physics, State University of New York at Stony Brook, Stony Brook, New York, United States of America.
Flexibility in biomolecular recognition is essential and critical for many cellular activities. Flexible recognition often leads to moderate affinity but high specificity, in contradiction with the conventional wisdom that high affinity and high specificity are coupled. Furthermore, quantitative understanding of the role of flexibility in biomolecular recognition is still challenging.
View Article and Find Full Text PDFWords of wisdom. Re: Topography of lymph node metastases in prostate cancer patients undergoing radical prostatectomy and extended lymphadenectomy: results of a combined molecular and histopathologic mapping study.
Eur Urol
February 2014
Department of Urology, University of Leipzig, Leipzig, Germany.
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